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커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.3
- 수록면
- 10 - 22 (13page)
- DOI
- 10.7841/ksbbj.2020.35.1.10
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초록· 키워드
오류제보하기
Nanoparticles have various advantages as drug carriers, so they have been widely used to deliver various chemical and biomolecule drugs, such as anti-cancer drugs and therapeutic proteins. Among nanoparticles, protein nanoparticles are non-cytotoxic and biodegradable, with high potential as drug carriers. Protein nanoparticles can be synthesized using proteins such as silk protein fibroin, albumin, gelatin, gliadin, legumin, 30Kc19 protein derived from silkworm hemolymph, and are manufactured using methods such as emulsion/solvent extension, desolvation, electrospray technology, complexification, and etc. The characterization parameters of protein nanoparticles are particle size, particle morphology and structure, surface charge, drug loading and release, which vary the drug delivery efficiency according to these parameters. Thus, the synthesis of protein nanoparticles using various materials and manufacturing techniques is being actively studied to improve drug delivery efficiency.
목차
Abstract
1. INTRODUCTION
2. 단백질 나노입자 제조에 사용되는 단백질 종류
3. 단백질 나노입자 제조 방법
4. 단백질 나노입자 특성
5. 약물 로딩 및 방출
6. CONCLUSION
REFERENCES
참고문헌 (80)
참고문헌 신청
Verma, D. / 2018 / Protein based nanostructures for drug delivery / Int. J. Pharm.
Davidov-Pardo, G. / 2015 / Foodgrade protein-based nanoparticles and microparticles for bioactive delivery: fabrication, characterization, and utilization / Adv. Protein. Chem. Str. Elsevier :293~325
Numata, K. / 2010 / Silk-based delivery systems of bioactive molecules / Adv Drug Deliver Rev 62:1497~1508
DeFrates, K. / 2018 / Protein polymer-based nanoparticles:fabrication and medical applications / Int. J. Mol. Sci. 19:1717
Qi, Y. / 2017 / A review of structure construction of silk fibroin biomaterials from single structures to multi-level structures / Int. J. Mol. Sci 18:237
Davidov-Pardo, G. / 2015 / Foodgrade protein-based nanoparticles and microparticles for bioactive delivery: fabrication, characterization, and utilization / Adv. Protein. Chem. Str. Elsevier :293~325
Numata, K. / 2010 / Silk-based delivery systems of bioactive molecules / Adv Drug Deliver Rev 62:1497~1508
DeFrates, K. / 2018 / Protein polymer-based nanoparticles:fabrication and medical applications / Int. J. Mol. Sci. 19:1717
Qi, Y. / 2017 / A review of structure construction of silk fibroin biomaterials from single structures to multi-level structures / Int. J. Mol. Sci 18:237
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UCI(KEPA) : I410-ECN-0101-2020-470-000539446