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(Korea Food Research Institute) (Korea Food Research Institute) (Korea Food Research Institute) (Korea Food Research Institute) (Korea Food Research Institute) (Korea Food Research Institute)
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한국식품영양과학회 한국식품영양과학회 학술대회발표집 2021 KFN International Symposium and Annual Meeting [초록집]
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    The purpose of this study is to determine the potential of piceatannol (PT) in statin resistance and tolerance related with hypercholesterolemia. We investigate the epigenetic mechanisms of proprotein convertase subtilisin/Kexin type 9 (PCSK9) expression through p300 acetyltransferase inhibition activity. HepG2 cells were used for in vitro study and exposed to statins (rosuvastatin or simvastatin) with PT in delipidated serum (DLPS) medium for cholesterol in starvation. Statin was treated the HepG2 cells with mevalonate in DLPS medium. An in vivo study was performed with hypercholestero ... 전체 초록 보기

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