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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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- 자료유형
- 학술저널
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- 2019.1
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D-penicillamine has been reported to cause antineutrophil cytoplasmic antibody (ANCA)- associated vasculitis presenting as rapidly progressive glomerulonephritis or pulmonary- renal syndrome mostly in adults. We report a pediatric case of D-penicillamine induced ANCA-associated vasculitis that manifests as a pulmonary-renal syndrome with a mild renal manifestation. A 13-year-old girl who has been taking D-penicillamine for five years under the diagnosis of Wilson disease visited the emergency room because of hemoptysis and dyspnea. She had diffuse pulmonary hemorrhage, microscopic hematuria, and proteinuria. Myeloperoxidase ANCA was positive, and a renal biopsy revealed pauci-immune crescentic glomerulonephritis. Under the diagnosis of D-penicillamine-induced ANCA-associated vasculitis, D-penicillamine was switched to trientine, and the patient was treated with plasmapheresis, glucocorticoid, cyclophosphamide, and mycophenolate mofetil. Pulmonary hemorrhage improved rapidly followed by the disappearance of the hematuria and proteinuria five months later.
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참고문헌 (35)
참고문헌 신청
Hutton HL / 2017 / ANCA-associated vasculitis : pathogenesis, models, and preclinical testing / Semin Nephrol 37(5):418~435
Hogan JJ / 2015 / Drug-induced glomerular disease : immune-mediated injury / Clin J Am Soc Nephrol 10(7):1300~1310
Banfi G / 1983 / Extracapillary glomerulonephritis with necrotizing vasculitis in D-penicillamine-treated rheumatoid arthritis / Nephron 33(1):56~60
Sadjadi SA / 1985 / Rapidly progressive glomerulonephritis in a patient with rheumatoid arthritis during treatment with high-dosage D-penicillamine / Am J Nephrol 5(3):212~216
Williams AJ / 1986 / Progressive proliferative glomerulonephritis in a patient with rheumatoid arthritis treated with D-penicillamine / Ann Rheum Dis 45(1):82~84
Hogan JJ / 2015 / Drug-induced glomerular disease : immune-mediated injury / Clin J Am Soc Nephrol 10(7):1300~1310
Banfi G / 1983 / Extracapillary glomerulonephritis with necrotizing vasculitis in D-penicillamine-treated rheumatoid arthritis / Nephron 33(1):56~60
Sadjadi SA / 1985 / Rapidly progressive glomerulonephritis in a patient with rheumatoid arthritis during treatment with high-dosage D-penicillamine / Am J Nephrol 5(3):212~216
Williams AJ / 1986 / Progressive proliferative glomerulonephritis in a patient with rheumatoid arthritis treated with D-penicillamine / Ann Rheum Dis 45(1):82~84
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