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자료유형
학술저널
저자정보
(Department of Internal Medicine Hanyang University College of Medicine Seoul Korea.) (Department of Pathology Hanyang University College of Medicine Seoul Korea.) (Department of Computer Science and Engineering College of Engineering Hanyang University Seoul Kore) (Department of Computer Science and Engineering College of Engineering Hanyang University Seoul Kore) (Department of Radiology Hanyang University College of Medicine Seoul Korea.) (Department of Surgery Hanyang University College of Medicine Seoul Korea.) (Department of Surgery Hanyang University College of Medicine Seoul Korea.) (Department of Surgery Hanyang University College of Medicine Seoul Korea.) (Department of Surgery Hanyang University College of Medicine Seoul Korea.) (Department of Surgery Hanyang University College of Medicine Seoul Korea.) (Department of Internal Medicine Hanyang University College of Medicine Seoul Korea.) (Division of Liver Transplantation and Hepatobiliary Surgery Department of Surgery University of Uls) (Division of Liver Transplantation and Hepatobiliary Surgery Department of Surgery University of Uls) (Department of Laboratory Medicine Hanyang University College of Medicine Seoul Korea.) (Department of Pathology Hanyang University College of Medicine Seoul Korea.) (Department of Pathology Hanyang University College of Medicine Seoul Korea.) (Department of Computer Science and Engineering College of Engineering Hanyang University Seoul Kore) (Department of Surgery Hanyang University College of Medicine Seoul Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.28
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초록· 키워드

Background: Cholecystitis is an important risk factor for gallbladder cancer, but the bile microbiome and its association with gallbladder disease has not been investigated fully. We aimed to analyze the bile microbiome in normal conditions, chronic cholecystitis, and gallbladder cancer, and to identify candidate bacteria that play an important role in gallbladder carcinogenesis. Methods: We performed metagenome sequencing on bile samples of 10 healthy individuals, 10 patients with chronic cholecystitis, and 5 patients with gallbladder cancer, and compared the clinical, radiological, and pathological characteristics of the participants. Results: No significant bacterial signal was identified in the normal bile. The predominant dysbiotic bacteria in both chronic cholecystitis and gallbladder cancer were those belonging to the Enterobacteriaceae family. Klebsiella increased significantly in the order of normal, chronic cholecystitis, and gallbladder cancer. Patients with chronic cholecystitis and dysbiotic microbiome patterns had larger gallstones and showed marked epithelial atypia, which are considered as precancerous conditions. Conclusion: We investigated the bile microbiome in normal, chronic cholecystitis, and gallbladder cancer. We suggest possible roles of Enterobacteriaceae, including Klebsiella, in gallbladder carcinogenesis. Our findings reveal a possible link between a dysbiotic bile microbiome and the development of chronic calculous cholecystitis and gallbladder cancer.
#Microbiota #Bile #Gallbladder Diseases #Gallbladder Neoplasms #Chronic Cholecystitis
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