지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 8 (8page)
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Previous animal studies have not conclusively determined the association between exposure to humidifier disinfectants (HDs) containing 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and/or 2-methyl-4-isothiazolin-3-one (MIT) and development of HD-associated lung injuries. Nonetheless, patients exposed to HDs containing only CMIT and/or MIT showed clinically similar lung injuries to those exposed to HDs containing polyhexamethylene guanidine (PHMG) or oligo (2-[2-ethoxy]ethoxyethyl) guanidinium chloride (PGH). Here, we report twin sisters with lung injuries associated with exposure to CMIT/MIT-containing HDs. At 6 months of age, a younger twin sister presented with the 3-day history of cough, sputum, and respiratory difficulty. Chest radiography revealed multiple patchy consolidation and ground-glass opacities with pneumothorax and pneumomediastinum. Thoracostomy was performed due to pneumothorax at admission and she was discharged at 11 days of hospitalization. At 5 years of age, multiple tiny nodules and faint centrilobular ground-glass opacities were observed with the small pneumatocele. The elder sister visited a tertiary hospital due to dyspnea at 12 months of age. Chest radiography showed consolidation, pneumomediastinum, and pulmonary interstitial emphysema. There was no response to the administration of immunosuppressant drugs and antifibrotic agents. At 5 years of age, chest CT revealed ground-glass opacity and multiple tiny centrilobular ground-glass opacities nodules in both lungs with exercise intolerance.
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참고문헌 (27)
참고문헌 신청
전종근 / 2008 / 2006년 초에 유행한 소아 급성 간질성폐렴 / Korean Journal of Pediatrics 51(4):383~390
김병주 / 2009 / 급성 간질성 폐렴의 전국적 현황 조사 / Korean Journal of Pediatrics 52(3):324~329
Kim KW / 2014 / Humidifier disinfectant-associated children's interstitial lung disease / Am J Respir Crit Care Med 189(1):48~56
Kim JY / 2013 / Acute cardiovascular toxicity of sterilizers, PHMG, and PGH: severe inflammation in human cells and heart failure in zebrafish / Cardiovasc Toxicol 13(2):148~160
Paek D / 2015 / Nationwide study of humidifier disinfectant lung injury in South Korea, 1994-2011. Incidence and dose-response relationships / Ann Am Thorac Soc 12(12):1813~1821
김병주 / 2009 / 급성 간질성 폐렴의 전국적 현황 조사 / Korean Journal of Pediatrics 52(3):324~329
Kim KW / 2014 / Humidifier disinfectant-associated children's interstitial lung disease / Am J Respir Crit Care Med 189(1):48~56
Kim JY / 2013 / Acute cardiovascular toxicity of sterilizers, PHMG, and PGH: severe inflammation in human cells and heart failure in zebrafish / Cardiovasc Toxicol 13(2):148~160
Paek D / 2015 / Nationwide study of humidifier disinfectant lung injury in South Korea, 1994-2011. Incidence and dose-response relationships / Ann Am Thorac Soc 12(12):1813~1821
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