인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Collagen hydrogel systems have been limited in their uses for hard tissue engineering due to their poormechanical properties in spite of their excellent biocompatibility. Physical strengthening and incorporation of theinorganic substances are considered as promising ways to improve mechanical stability of the collagen gel, whileproviding effective biomimetic environment for cells. Here, we developed three-dimensional matrix by rolling upthe plastically-compressed collagen hydrogel composites with mesoporous bioactive glass nanoparticle (BGn).
Monodispersed BGn with a size of ~90 nm was well incorporated within the collagen matrix which has nanofibrillarstructure. The mechanical properties of the composite hydrogels measured by dynamic mechanical analysis weresignificantly improved by the compression of the hydrogels and further improved by addition of BGn into hydrogels.
Moreover, the proliferation rate and osteogenic differentiation of rat bone marrow derived mesenchymal stem cellscultured within the composite hydrogels were enhanced by incorporation of BGn. The results suggest that physically-strengthened nanocomposite collagen hydrogel would be useful in hard tissue engineering applications.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.