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논문 기본 정보

자료유형
학술저널
저자정보
(Tong-Myong University)
저널정보
한국체육과학회 한국체육과학회지 한국체육과학회지 제30권 제6호 (자연과학 편)
발행연도
수록면
739 - 750 (12page)
DOI
10.35159/kjss.2021.12.30.6.739

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초록· 키워드

Vascular Dementia(VaD) causes changes in the hippocampus that may lead to cognitive decline in rats. In rat animals with VaD, exercise increases hippocampal neurogenesis and serotonin. We investigated whether treadmill exercise would benefit rats that were sedentary until 19 months of age. Specifically, rats were housed with or without treadmill exercise and injected with bromodeoxyuridine or retrovirus to label newborn cells. Exercise rats showed increase of hippocampal neurogenesis and serotonin in raphe compare to the VaD-induced rats. The decline in neurogenesis in VaD-induced rats was reversed to 50% of Sham group levels by running. Moreover, fine morphology of new neurons did not differ between sham groups and VaD+EXE group, indicating that the initial maturation of newborn neurons was not affected by VaD+EXE. Thus, voluntary exercise ameliorates some of the deleterious morphological and decreased serotonin expression of rats with VaD.
#Exercise #Neurogenesis #Vascular Dementia #5-HT
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목차

  1. Abstract
  2. Ⅰ. Introduction
  3. Ⅱ. Materials and Methods
  4. Ⅲ. Results
  5. Ⅳ. Discussion
  6. References

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