지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Purine metabolism is known factor for nuclear maturation of oocytes through both follicle cells and oocyte itself. However, it is largely unknown the roles of purine metabolism in the oocyte competence for fertilization and early development. In this study, the effects of adenosine in oocyte competence for development were examined using adenosine and its synthetic inhibitors. Adenosine treatment from GV intact stage for 18 hr (fGV) caused of decrease the fertilization rate but of increase the cleavage rate compared from the other stage treatment groups. Hadacidin did not effect on fertilization rate but increased cleavage rate without stage specificity. Adenosine did not block the effects of hadacidin with the exception of fGV group. Inhibition of purine synthetic pathways the fertilization rate was decreased in the fGV and fGVB groups but increased in the fMII group. Exogenous adenosine caused of decrease fertilization rate in the fGVB group but increase in the fMII group. Cleavage rate was dramatically increased in the adenosine treatment with synthetic inhibitors. It means that the metabolism of purine has stage specific effects on fertilization and cleavage. Exogenous adenosine had only can improve oocyte developmental competence when it treated at GV intact stage. On the other hand, endogenous synthesis in all maturation stage cause of increase the cleavage rate without effects on fertilization. These data suggest that adenosine at GV stage as a paracrine fashion and inhibitions of endogenous adenosine in all stage improve oocyte developmental competence..
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참고문헌 (25)
참고문헌 신청
Berg JM / 2002 / Biochemistry / WH Freeman
Cheon YP / 1997 / Effects of adenosine, guanosine nad azaserine on maturation of mouse oocytes in vitro / Korean J Animal Reprod 21 : 123 ~ 130
Cho WK / 1974 / Inhibition effect of dibutyryl cAMP on mouse oocyte maturation in vitro / J Exp Zool 187 : 383 ~ 386
Conti M / 2005 / Role of the EGF network in ovarian follicles / Mol Endocrinol 20 : 715 ~ 723
Conti M / 2012 / Novel signaling mechanisms in the ovary during oocyte maturation and ovulation / Mol Cell Endocrinol 356 : 65 ~ 73
Cheon YP / 1997 / Effects of adenosine, guanosine nad azaserine on maturation of mouse oocytes in vitro / Korean J Animal Reprod 21 : 123 ~ 130
Cho WK / 1974 / Inhibition effect of dibutyryl cAMP on mouse oocyte maturation in vitro / J Exp Zool 187 : 383 ~ 386
Conti M / 2005 / Role of the EGF network in ovarian follicles / Mol Endocrinol 20 : 715 ~ 723
Conti M / 2012 / Novel signaling mechanisms in the ovary during oocyte maturation and ovulation / Mol Cell Endocrinol 356 : 65 ~ 73
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