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논문 기본 정보

자료유형
학술저널
저자정보
(Department of Gastroenterology) (Division of Gastroenterology and Hepatology, Stanford University Medical Centre, Palo Alto, CA, USA; Harvard Medical School, Boston, MA, USA) (Genomics Research Centre, Academia Sinica, Taipei, Taiwan; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Graduate Institute of Medicine, College o) (Department of Infectious Disease, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China) (Division of Gastroenterology and Hepatology, Stanford University Medical Centre, Palo Alto, CA, USA; Larner College of Medicine, University of Vermont, Burlington, VT, USA) (Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan) (Yong Loo Lin School of Medicine, National University of Singapore, Singapore) (Yong Loo Lin School of Medicine, National University of Singapore, Singapore) (Department of Gastroenterology) (Lane library, Stanford University School of Medicine, Palo Alto, CA, USA) (Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China) (Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China) (Department of Infectious Disease, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China) (Department of Infectious Disease, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China) (Department of Pathology, Singapore General Hospital, Singapore) (SingHealth Duke-NUS Medicine Academic Clinical Program, Singapore; Department of Gastroenterology) (Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Centre, Palo Alto, CA, USA; Division of Gastroenterology and Hepatology, Veterans Affairs Pal) (Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Hong Kong) (Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Hong Kong) (Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan) (Division of Gastroenterology and Hepatology, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA; Department of Epidemiology and Population Health, Stanford University, Stanfor)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology Vol.29 No.3
발행연도
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705 - 720 (16page)

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초록· 키워드

Background/Aims: Chronic hepatitis B (CHB) and fatty liver (FL) often co-exist, but natural history data of this dual condition (CHB-FL) are sparse. Via a systematic review, conventional meta-analysis (MA) and individual patient-level data MA (IPDMA), we compared liver-related outcomes and mortality between CHB-FL and CHB-no FL patients. Methods: We searched 4 databases from inception to December 2021 and pooled study-level estimates using a random- effects model for conventional MA. For IPDMA, we evaluated outcomes after balancing the two study groups with inverse probability treatment weighting (IPTW) on age, sex, cirrhosis, diabetes, ALT, HBeAg, HBV DNA, and antiviral treatment. Results: We screened 2,157 articles and included 19 eligible studies (17,955 patients: 11,908 CHB-no FL; 6,047 CHB-FL) in conventional MA, which found severe heterogeneity (I2=88–95%) and no significant differences in HCC, cirrhosis, mortality, or HBsAg seroclearance incidence (P=0.27–0.93). IPDMA included 13,262 patients: 8,625 CHB-no FL and 4,637 CHB-FL patients who differed in several characteristics. The IPTW cohort included 6,955 CHB-no FL and 3,346 CHB-FL well-matched patients. CHB-FL patients (vs. CHB-no FL) had significantly lower HCC, cirrhosis, mortality and higher HBsAg seroclearance incidence (all P≤0.002), with consistent results in subgroups. CHB-FL diagnosed by liver biopsy had a higher 10-year cumulative HCC incidence than CHB-FL diagnosed with non-invasive methods (63.6% vs. 4.3%, P<0.0001). Conclusions: IPDMA data with well-matched CHB patient groups showed that FL (vs. no FL) was associated with significantly lower HCC, cirrhosis, and mortality risk and higher HBsAg seroclearance probability.
#Non-alcoholic fatty liver disease #Hepatocellular carcinoma #Mortality #HBsAg seroclearance #Fibrosis #Cirrhosis
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