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저자정보
(Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Korea.Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Ce) (Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.) (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.) (Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.) (Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.) (Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.) (Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.) (Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.) (Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.) (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.) (Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Korea.) (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.) (Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.) (Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.) (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.) (Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research AAIR Vol.15 No.6
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    초록·키워드

    Allergic diseases are a major public health problem with increasing prevalence. These immune-mediated diseases are characterized by defective epithelial barriers, which are explained by the epithelial barrier theory and continuously emerging evidence. Environmental exposures (exposome) including global warming, changes and loss of biodiversity, pollution, pathogens, allergens and mites, laundry and dishwasher detergents, surfactants, shampoos, body cleaners and household cleaners, microplastics, nanoparticles, toothpaste, enzymes and emulsifiers in processed foods, and dietary habits are responsible for the mucosal and skin barrier disruption. Exposure to barrier-damaging agents causes epithelial cell injury and barrier damage, colonization of opportunistic pathogens, loss of commensal bacteria, decreased microbiota diversity, bacterial translocation, allergic sensitization, and inflammation in the periepithelial area. Here, we review scientific evidence on the environmental components that impact epithelial barriers and microbiome composition and their influence on asthma and allergic diseases. We also discuss the historical overview of allergic diseases and the evolution of the hygiene hypothesis with theoretical evidence.
    #Allergy #asthma #barrier #exposome #microbiota #microbiome #environment #exposure #climate #pollution

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