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자연과학
공학
의약학
농수해양학
예술체육학
복합학
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2025.3
- 수록면
- 49 - 54 (6page)
- DOI
- 10.20307/nps.2025.31.1.49
이용수
초록· 키워드
Oxidative stress, a key factor in the progression of brain diseases, induces apoptosis through multiple pathways. This study investigates the protective effects of Euonymus elatus, a traditional Korean remedy for conditions such as atherosclerosis, dysmenorrhea, and pain, on neuronal cells under oxidative stress. Excess glutamate was used to model oxidative stress, resulting in elevated reactive oxygen species (ROS), increased intracellular calcium (Ca²⁺), reduced mitochondrial membrane potential, and decreased activity of glutathione-related enzymes, including glutathione reductase (GR) and glutathione peroxidase (GPx). Experimental results revealed that E. elatus extract provided significant cytoprotective effects. The extracts improved cell viability in MTT assays, reduced ROS and Ca²⁺ levels, restored mitochondrial membrane potential, and enhanced the activity of GR and GPx. These findings highlight the potential of E. elatus as a therapeutic candidate for mitigating oxidative stress and treating neurodegenerative disorders, such as Alzheimer’s disease.
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목차
- Abstract
- Introduction
- Experimental
- Results and Discussion
- References
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