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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.16 No.1
- 발행연도
- 2011.3
- 수록면
- 18 - 23 (6page)
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초록· 키워드
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by neuronal loss and extracellular senile plaques containing β-amyloid peptide (Aβ). The deposition of the Aβ peptide following proteolytic processing of amyloid precursor protein (APP) by β-secretase (BACE1) and γ-secretase is a critical feature in the progression of AD. Among the plant extracts tested, the ethanol extract of Petasites japonicus leaves showed novel protective effect on B103 neuroblastoma cells against neurotoxicity induced by Aβ, as well as a strong suppressive effect on BACE1 activity. Ethanol extracts of P. japonicus leaves were sequentially extracted with methylene chloride, ethyl acetate and butanol and evaluated for potential to inhibit BACE1, as well as to suppress Aβ-induced neurotoxicity. Exposure to Aβ significantly reduced cell viability and increased apoptotic cell death. However, pretreatment with ethyl acetate fraction of P. japonicus leaves prior to Aβ (50 μM) significantly increased cell viability (p＜0.01). In parallel, cell apoptosis triggered by Aβ was also dramatically inhibited by ethyl acetate fraction of P. japonicus leaves. Moreover, the ethyl acetate fraction suppressed caspase-3 activity to the basal level at 30 ppm. Taken together, these results demonstrated that P. japonicus leaves appear to be a useful source for the inhibition and/or prevention of AD by suppression of BACE1 activity and attenuation of Aβ induced neurocytotoxicity.
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목차
- Abstract
- INTRODUCTION
- MATERIALS AND METHODS
- RESULTS AND DISCUSSION
- ACKNOWLEDGEMENTS
- REFERENCES
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UCI(KEPA) : I410-ECN-0101-2012-511-004225819
