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Anti-wrinkle Effects of Black Snow, Sun, and Red Ginseng Water Extracts on Human Dermal Fibroblasts

논문 기본 정보

저자정보
(Daegu Technical University) (Gyongbuk Science College) (Keimyung University)
저널정보
계명대학교 자연과학연구소 Quantitative Bio-Science Quantitative Bio-Science Vol.37 No.1
발행연도
수록면
49 - 55 (7page)
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Anti-wrinkle Effects of Black Snow, Sun, and Red Ginseng Water Extracts on Human Dermal Fibroblasts
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    초록·키워드

    A variety of commercially processed ginseng products, including black snow ginseng (BSG), sun ginseng (SG), and red ginseng (RG) are currently available in the market. To evaluate the anti-wrinkle effects of Panax ginseng (BSG, SG, and RG) water extracts (PGWEs: BSGWE, SGWE, and RGWE), collagen synthesis and degradation abilities of PGWEs were assessed using human dermal fibroblasts. BSGWE, SGWE, and RGWE at the concentration of 50 ㎍/mL increased type-I procollagen synthesis by 82.7% (p<0.001), 26.9% (p<0.01), and 119.2% (p<0.001), respectively, in comparison to control cells. In comparison to control cells, treatments with 50 ㎍/mL of BSGWE, SGWE, and RGWE significantly (p<0.001) decreased the activity of matrix metalloproteinase-2 (MMP-2) and the mRNA and protein expression of MMP-1. PGWEs were found to promote collagen synthesis and inhibit its degradation in human dermal fibroblasts. Among PGWEs, RGWE showed the most effective anti-wrinkle effects.

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      UCI(KEPA) : I410-ECN-0101-2018-047-002155024