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초록·키워드
Background: Persimmon leaf (Diospyros kaki), green tea (Camellia sinensis), and sophora fruit (Sophora japonica) are traditional food sources known to prevent oxidative stress and inflammation. However, research on their effect in reducing hair loss is lacking. The purpose of this study was to determine whether an extract mading using these plants, BLH308 could help reduce hair loss.
Methods and Results: The antioxidant activity of BLH308 in vitro was investigated as well as its anti-inflammatory effect in RAW 264.7 cells and its effect on the expression of 5-alpha reductase Ⅱ in human dermal papilla cells. BLH308 showed significant antioxidant activity owing to its ability to scavenge 2,2-diphenyl-1-picrylhydrazyl and 2,2"-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radicals. Moreover, BLH308 effectively inhibited the lipopolysaccharide-induced production of interleukin-6 and tumor necrosis factor-α in RAW 264.7 cells, and downregulated the expression of 5-alpha reductase Ⅱ in human dermal papilla cells. In vivo, the hair growth promoting effect was evaluated using hair growth visual scoring. BLH308 reduced hair loss in testosterone propionate-induced hair loss C57BL/6N mice by promoting the onset of growing phase of the hair growth cycle.
Conclusions: Our results showed that BLH308 can promote hair regeneration and repair hair loss, and is a potential novel candidate for the treatment of androgenetic alopecia.
Methods and Results: The antioxidant activity of BLH308 in vitro was investigated as well as its anti-inflammatory effect in RAW 264.7 cells and its effect on the expression of 5-alpha reductase Ⅱ in human dermal papilla cells. BLH308 showed significant antioxidant activity owing to its ability to scavenge 2,2-diphenyl-1-picrylhydrazyl and 2,2"-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radicals. Moreover, BLH308 effectively inhibited the lipopolysaccharide-induced production of interleukin-6 and tumor necrosis factor-α in RAW 264.7 cells, and downregulated the expression of 5-alpha reductase Ⅱ in human dermal papilla cells. In vivo, the hair growth promoting effect was evaluated using hair growth visual scoring. BLH308 reduced hair loss in testosterone propionate-induced hair loss C57BL/6N mice by promoting the onset of growing phase of the hair growth cycle.
Conclusions: Our results showed that BLH308 can promote hair regeneration and repair hair loss, and is a potential novel candidate for the treatment of androgenetic alopecia.
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