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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2001.12
- 수록면
- 249 - 253 (5page)
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Fumonisin B1, a mycotoxin, is thought to induce esophageal cancer in humans and apoptosis in animal cells by inhibiting ceramide synthase. Fumonisin B1 may also generate reactive oxygen species directly or indirectly, leading to DNA damage and lipid peroxidation. In this study, a DNA fragmentation assay, dichlorofluorescein (DCF) analysis, and single cell gel electrophoresis (SCGE) were used to investigate the involvement of cellular free radicals, specifically hydrogen peroxide, in the DNA damaging activity of fumonisin B1. From an in vitro DNA fragmentation assay, E. coli DNA damage by fumonisin B1 was increased by the addition of superoxide dismutase (SOD) and decreased by catalase. SCGE and DCF analysis in vivo showed that the nuclear DNA damage and intracellular free radicals in cultured rat hepatocytes treated with fumonisin B1 were increased with the concentration of fumonisin B1. DNA damage and free radical generation were inhibited by the addition of catalase. Fumonisin B1, in the presence of SOD, produces hydrogen peroxide causing oxidative DNA damage and protein malfunction, leading to genotoxicity and cytotoxicity of th toxin.
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The altered $Na^+,\;K^+$-pump activity following the fumonisin exposure to LLC-PKl cells
대한약학회 학술대회
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세균 바이러스 증식에 대한 fumonisin B1 의 영향 ( effect of fumonisin b1 on the bacterial virus multiplication )
한국독성학회지
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fumonisin 의 독성과 최근연구동향
한국독성학회보
1998 .06
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Differential Effects of Fumonisin $B_1$ on Cell Death in Cultured Cells: the Significance of the Elevated Sphinganine
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2001 .01
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apoptosis and cell proliferation induced by fumonisin b1 in rat liver
한국독성학회지
1998 .03
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The altered sphingolipid metabolism in rats following fumonisin B1 exposure
대한약학회 학술대회
2003 .01
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Fumonisin B1 causes autophagy in the mouse liver
대한체질인류학회 학술대회 연제 초록
2018 .05
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$LLC-PK_1$ 세포에서의 퓨모너신 $B_1$에 의해 유도된 스핑고리피드 대사
약학회지
1997 .01
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a limited survey of fumonisin b1 content of domestic and imported corns in korea
한국독성학회지
1997 .12
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Fumonisin B1 의 SD흰쥐에 대한 세포분열과 세포 독성작용 ( Mitogenic and Cytotoxic Effect of pure Fumonisin B1 , a carcinogen , in Sprague-Dawley Rats )
한국환경성돌연변이·발암원학회지
1996 .03
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Developmental and Neurobehavioral Effects of Mycotoxin Fumonisin B1 in Rats
Toxicological Research
2000 .06
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Developmental and Neurobehavioral Effects of Mycotoxin Fumonisin B1 in rats
대한약학회 학술대회
2000 .01
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Fumonisins, Mycotoxins, in Foods and Feeds : Their Toxicities and the Possible Toxic Mechanism
한국보건교육건강증진학회 학술대회 발표논문집
1997 .12
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Teratogenicity of Fumonisin in the Developing Chick Embryo
Laboratory Animal Research
1995 .06
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Fusarium Moniliforme 대사산물 Fumonisin B1의 세포 및 유전독성 ( Cytotoxic Action and Genotoxicity of Fusarium Moniliforme Metabolite Fumonisin B1 )
한국독성학회지
1994 .06
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Sphinganine 1-phosphate, New biomarker of fumonisin B1 exposure
대한약학회 학술대회
2002 .01
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Fumonisin B1 Contamination of Cereals and Risk of Esophageal Cancer in a High Risk Area in Northeastern Iran
Asian Pacific journal of cancer prevention : APJCP
2012 .01
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Disruption of Sphingolipid Metabolism as a Potential Mechanism of Fumonisin Inhibition of Cell Growth in LLC-PK1 Cells
한국독성학회지
1995 .03
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DNA damage to human genetic disorders with neurodevelopmental defects
Journal of genetic medicine
2016 .01
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UCI(KEPA) : I410-ECN-0101-2009-513-013456101