Initial Risk Assessment of Disodium Disulphite in OECD High Production Volume Chemical Program

Sanghwan Song; Yoonho Choi; Hye-Youn Park; Minjeong Kwon; Hyunju Koo; Seong-Hwan Jeon; Jin-Gyun Na; Kwangsil Park

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저자정보: Sanghwan Song Yoonho Choi Hye-Youn Park Minjeong Kwon Hyunju Koo Seong-Hwan Jeon Jin-Gyun Na Kwangsil Park

저널정보: 한국독성학회 Toxicological Research Journal of Toxicology and Public Health Vol.18 No.1

발행연도: 2002.3

수록면: 23 - 29 (7page)

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Disodium disulphite, the HPV chemical, was assigned to Korea in order to implement OECD SIDS program in 1999. It was produed about 3,200 ton/year in 1998. This report evaluates the toxic potency of disodium disuphite based on the environmental and mammalian effects as well as human exposure. Oral LD_(50) in rats is 1,540 mg/kg b.w. and effects was observed to the stomach, liver, and the GI track that was filled with blood. For repeated dose toxicity, the predominant effect was the induction of stomach lesions due to local irritation. The no observed adverse effect level for local (stomach irritation) was about 217 mg/kg bw/day. There is no evidence that disodium disulphite is genotoxic in vivo. No reproductive or developmental toxicity of disodium disulphite was observed for the period up to 2 yr and over three generations. In humans, urticaria and asthma with itching, edema, rhinitis, and nasal congestion were reported. Disodium disulphite is unlikely to induce respiratory sensitization but may enhance symptoms of asthma in sensitive individuals. This chemical would be mainly transported to water compartment when released to environmental compartments since it is highly water soluble (470 g/l at 20). Low K_(OC) (2.447) indicates disodium disulphite is so mobile in soil that it may not stay in the terrestrial compartment. The chemical has been tested in a limited number of aquatic species. From acute toxicity test to fish, 96 hr-LC_(50) was > 100 mg/l. For algae, 72hr-EC_(50) was 48.1 mg/l. For daphnid, the acute toxicity value of 48 hr-EC_(50) was 88.76 mg/l, and chronic value of 21day-NOEC was > 10 mg/l. Therefore, PNEC of 0.1 mg/l for the aquatic organisms was obtained from the chronic value of daphnid using the assessment factor of 100. Based on these data the disodium disulphite was recommended as low priority for further post-SIDS work in OECD.

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김민선, 김우일, 신선경, 강영렬, 조윤아, 정성경, 김나, 연진모, 이지영. 재활용 플라스틱 제품 중 고무대야의 중금속 노출량 평가. 분석과학. 2013

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