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To examine the role of protein kinase C (PKC) in regulation of interleukin-1 beta (IL-1β)-induced iNOS expression, IL-1β-induced nitrite production was observed in cultured vascular smooth muscle (VSM) cells pretreated with phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-butyrate (PDB) as PKC activator; 4α-phorbol-didecanoate (PDD) as PKC non-activator. Nitrite production induced by IL-1β was increased by the presence of increasing concentration of PMA ranging from 2 to 200 nM. However, in VSM cells pretreated with PMA and PDB, IL-1β-induced NO2 production was decreased in proportion to the duration of pretreatment, and most significantly decreased in pretreatment time of 24 hours. Using RT-PCR method, the expression of iNOS mRNA induced by IL-1β was decreased in VSM cells pretreated with PMA 200 nM for 24 hours. These results suggest that decrease in IL-Iβ-induced nitrite production by the pretreatment of PMA result from inhibition of iNOS expression and the inhibition related to PMA-induced PKC down-regulation.
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UCI(KEPA) : I410-ECN-0101-2009-470-014220550