3-MCPD의 생식˙발생독성에 관한 연구

곽승준; 김순선; 최요우; 이규식; 손경희; 이이다; 채수영; 정용현; 유일재; 박귀례

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자료유형: 학술저널

저자정보: 곽승준 김순선 최요우 이규식 손경희 이이다 채수영 정용현 유일재 박귀례

저널정보: 한국독성학회 Toxicological Research Journal of Toxicology and Public Health Vol.20 No.2

발행연도: 2004.6

수록면: 131 - 136 (6page)

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3-Monochloro-1,2-propanediol(3-MCPD) is a toxic compound, often present in different foods containing acid hydrolyzed(AH) protein, like seasonings and savory food products. The purpose of the present study was to investigate the effects of 3-MCPD on male fertility, sperm and testosterone secretion. In vivo male fertility test was performed for observing the adverse effects of 3-MCPD on the function of male reproductive system and pregnancy outcome. 0.01, 0.05, 0.25, 1 and 5 mg/kg b.w. of 3-MCPD was given daily by gavage to groups of 15 adult male SD rats for 4 weeks. At the end of pre-treatment period, males were mated overnight with normal females. Following morning, males demonstrating successful induction of pregnancy were sacrificed on that day to assess sperm parameters and histopathology of reproductive organs. The resulting pregnant females were sacrificed on day 20 of gestation to evaluate pregnancy outcome. As a result, four-week paternal administration with 3-MCPD resulted in adverse effects on male fertility and pregnancy outcome without remarkable histopathological changes in testes and epididymides; sperm motility, copulation index and fertility index were markedly decreased in the treated group and numbers of live fetuses showed steep dose-response curves. Also, spermatogenesis was investigated in this experiment. However, no
effect was observed on production of sperm in testes treated with 3-MCPD for 4 weeks. Hormone assay was performed for observing the effects of 3-MCPD on testosterone and luteinizing hormone (LH) in blood and testes of male SD rats and cultured primary Leydig cell. In result, significant changes of related hormones did not observed by treatment of 3-MCPD. These results indicated that paternal treatment with 3-MCPD induced spermatotoxic effect, which caused an antifertility on male.

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Seung Jun Kwack

소속기관 Changwon National University

주요연구분야 의약학 > 기초의학 > 예방의학·직업환경의학 농수해양학 > 농학

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김순선

소속기관 한국독성학회