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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.12
- 수록면
- 1,997 - 2,003 (7page)
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This paper presents a new method and an associated device, capable of detecting protein presence and size from the shift of the mechanical stiffness changing points due to the presence and size of proteins in a nano-gap actuator. Compared to the conventional resonant detection method, the present nanomechanical stiffness detection method shows higher precision for protein detection. The present method also offers simple and inexpensive protein detection devices by removing labeling process and optical components. We design and fabricate the nanomechanical protein detector using an electrothermal actuator with a nano-gap. In the experimental stutly, we measure the stiffness changing points and their coordinate shift from the devices with
and without target proteins. The fabricated device detects the protein presence and the protein size of 14.0±7.4nm based on the coordinate shift of stiffness changing points. We experimentally verify the protein presence and size detection capability of the nanomechanical protein detector for applications to high-precision biomolecule detection.
and without target proteins. The fabricated device detects the protein presence and the protein size of 14.0±7.4nm based on the coordinate shift of stiffness changing points. We experimentally verify the protein presence and size detection capability of the nanomechanical protein detector for applications to high-precision biomolecule detection.
목차
Abstract
1. 서론
2. 이론적 해석 및 설계
3. 제작공정
4. 성능시험 결과
5. 결론
후기
참고문헌
참고문헌 (8)
참고문헌 신청
[학술지(정기간행물)] - / 1999 / Sensors for Biomolecular Studies in Microsystem Technology: A Powerful Tool for Biomolecular Studies 12.
[학술지(정기간행물)] - / 20032003 / Vapor and Liquid Mass Sensing by Micromachined Acoustic Resonator : 470 ~ 473
[학술지(정기간행물)] - / 1997 / QCM Operation in Liquids Constant Sensitivity during Formation of Extended Protein Multilayers by Affinity 69 (7) : 1441 ~ 1448
[학술지(정기간행물)] - / 1987 / New Approaches to Electrochemical Immunoassays in Biosensors: Fundamentals and Applications
[학술지(정기간행물)] - / 1998 / Ligand Assays:from Electrophoresis to Miniaturized Microarrays 44 (9) : 2015 ~ 2030
[학술지(정기간행물)] - / 20032003 / Vapor and Liquid Mass Sensing by Micromachined Acoustic Resonator : 470 ~ 473
[학술지(정기간행물)] - / 1997 / QCM Operation in Liquids Constant Sensitivity during Formation of Extended Protein Multilayers by Affinity 69 (7) : 1441 ~ 1448
[학술지(정기간행물)] - / 1987 / New Approaches to Electrochemical Immunoassays in Biosensors: Fundamentals and Applications
[학술지(정기간행물)] - / 1998 / Ligand Assays:from Electrophoresis to Miniaturized Microarrays 44 (9) : 2015 ~ 2030
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UCI(KEPA) : I410-ECN-0101-2009-550-014427981