메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색
질문

논문 기본 정보

자료유형
학술저널
저자정보
저널정보
고려인삼학회 Journal of Ginseng Research 고려인삼학회지 제29권 제2호
발행연도
2005.6
수록면
100 - 106 (7page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색
질문

초록· 키워드

오류제보하기
The number of reporting the effects on ginseng's physiological, pharmacological, and behavioral effects has been increased every year. Major active components of Panax ginseng, are the ginsenosides, which are mainly triterpenoid dammarane derivatives. 3-Nitropropionic acid (3-NP) is mown to induce cellular energy deficit and oxidative stress related neurotoxicity via an irreversible inhibition of the mitochondrial enzyme succinate dehydrogenase (SDH). Intraperitoneal injection of 3-NP produces striatal degeneration. Aged animals was more vulnerable to 3-NP than young animal. We used three different ages of 5-, 8-, and 26-week-old rats. 3-NP alone treatment induced striatal lesion and increased lesion volume with age-dependent manner in 5-,8-, and 26-week-old rats by 30.2±5.8, 37.38±6.1, and 51.3±8.4㎣, respectively. However, pretreatment of GTS (100㎎/㎏/day) before 3-NP reduced striatal lesion in 5-, 8-, and 26-week-old rats by 3.15±6.1, 8.89±1.9, and 27.3±5.6㎣ , respectively. Pretreatment of GTS also significantly increased survival rate in 5-week-old rats (3-NP alone: GTS+3-NP=40.4±6.3: 72.5±9.5%) than 8-week-o]d rats (3-NP alone: GTS+3-NP=13.5±5.2% : 45.1±3.1%). In 26-week-old rats, 3-NP alone treated group died on day 18, whereas GTS+3-NP-treated group prolonged lifespan to 30 days. Thus, pretreatment of GTS before administration of 3-NP extended lifespan in all ages. The present results indicate that aged animals are more vulnerable to 3-NP and GTS pretreatment protected 3-NP-induced striatal damage in different ages of animals.

목차

Abstract

1. INTRODUCTION

2. MATERIALS AND METHODS

3. RESULTS

4. DISCUSSION

ACKNOWLEDGMENTS

REFERENCES

참고문헌 (0)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0

UCI(KEPA) : I410-ECN-0101-2009-524-017764365