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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2001.12
- 수록면
- 74 - 87 (14page)
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Evidence shows that the serum level of cholesterol (CH) is decreased with increasing green tea (GT) consumption. This presentation summarizes our recent findings on the effect of GT extract on intestinal absorption of ¹⁴C-labeled CH and phosphatidy1choline (PC). Ovariectomized (OX) adult rats were infused intraduodenally with lipid emulsions containing radiolabeled lipids [¹⁴C-CH or ¹⁴C-phosphatidy1choline (PC)] in the presence of GT extract or catechins to determine the rates and amounts of CH absorption and the intestinal hydrolysis and lymphatic output of PC. During lipid infusion, lymph was collected hourly for 8 h. The lymphatic absorption of ¹⁴C-CH was drastically lowered by infusion of GT extract at two dosage levels (GTl = 5.4 ㎎ catechins/h and GT2 = 15.1 ㎎ catechins/h). The cumulative lymphatic absorptions of ¹⁴C-CH in rats infused with GT1 and GT2 were 20.7 ± 4.3 and 4.8 ± 4.1% dose, respectively, whereas the absorption of ¹⁴C-CH in rats infused with no GT extract (GT0) was 36.3 ± 1.1% dose. GT extracts also significantly lowered the absorption of -tocopherol (TP) in a dose dependent manner (29.6 ± 4.9% dose in GT0, 20.8 ± 5.8% dose in GT1, and 7.9 ± 5.4% dose in GT2 groups). Both (+)-catechin and EGCG significantly lowered the lymphatic outputs of ¹⁴C-radioactivity after intraduodenal ¹⁴C-PC infusion. A significantly higher amount of ¹⁴C-PC remained unhydrolyzed in the intestinal lumen of the EGCG rats (22.8%) compared with the (+)-catechin (15.8%) and control groups (11.9%). GT extracts, (+)-catechin, and EGCG significantly reduced the absorption of TP. The inhibitory effect of GT extract and catechins on lipid absorption may be mediated in part through the inhibition of pancreatic PLA₂. The findings provide the first direct evidence that green tea and catechins have a profound inhibitory effect on the intestinal absorption of CH in OX rats. Results suggest that green tea and catechins may be used as a dietary or pharmacological means of lowering cholesterol absorption.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
References
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(+) - Catechin is a Potent Inhibitor of Intestinal Absorption of Cholesterol in Rats
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Bioavailability and Efficiency of Tea Catechins as an Antioxidant
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Effect of Enteric Coating Materials on Digestive Stability and Absorption of Green Tea Catechins
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Inhibitory Effects of Green Tea Catechins on Virulence Factors in Periodontopathogens
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Mechanism of Scavenging Reactive Oxygen Species of Tea catechins
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[P2-80] Analysis of Catechin and Caffeine in Four Varieties of Jeju Green Teas according to the Harvest Season
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2008 .10
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Medicinal Actions of Green Tea Catechins : Modulation of Endocrine Systems and Obesity
한국식품과학회 심포지엄
2001 .06
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Combined Effects of Formulation and Encapsulation on Digestive Stability and Intestinal Transport of Green Tea Catechins
한국식품영양과학회 학술대회발표집
2013 .11
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Effects of Green Tea Catechin on Serum Lipid Composition and Angiotensin - Converting Enzyme Activity in Rats Exposed to Microwave
Journal of Food Science and Nutrition
2004 .06
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차에서 추출한 catechin(카테킨)의 항산화효과 및 항균활성효과
한국원예학회 학술발표요지
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