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    초록·키워드

    p16^(INK4a) is a tumor suppressor that belongs to the INK4 family of the cyclin D-dependent kinases (cdk) inhibitors. It plays regulatory roles in cell proliferation and in tumorigenesis by interacting with Rb signaling. Abnormally elevated p16^(INK4a) protein expression causes cell cycle arrest (G1/S transition) and loss of cyclincdk activity. In many cancers, p16^(INK4a) is altered by mutation, deletion, and promoter methylation. This review summarizes the function of p16 as an important regulator of cancer pathobiology and a promising target for developing cancer therapeutic and chemopreventive agents.

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      UCI(KEPA) : I410-ECN-0101-2009-476-015284796