인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Objective : The purpose of this study was to examine the regional cerebral blood-flow(rCBF) difference between boys with pure ADHD and normal controls before and after methylphenidate treatment, and also we examined the association between rCBF changes and cognitive characteristics of boys with pure ADHD before and after methylphenidate treatment.
Methods : The rCBF of 5 boys with pure ADHD and 5 control boys were examined by Tc-99m ECD brain SPECT and cognitive characteristics by ADS and every 5 ADHD boys took MPH for 12 to 16 weeks. After that all ADHD boys took Tc-99m ECD brain SPECT and checked ADS again. rCBF difference and changes before and after MPH treatment were quantified and analyzed by using SPM. And, associations between types of cognitive changes measured by ADS and rCBF changes were examined, and quantitative associations between them were also analyzed by using Pearson's coefficient correlation.
Results : 1) Before MPH treatment, rCBF of ADHD boys were significantly decreased in left orbitofrontal area and left caudate nucleus compared to normal controls. 2) After MPH treatment, rCBF of the same regions were significantly increased. 3) There was positive correlation between the degree of commission error(impulsivity, disinhibition) among the ADS variables and the degree of blood-flow decrease in above two areas before MPH treatment but after MPH treatment, only with the degree of rCBF increase in Lt orbitofrontal area.
Conclusion : These results suggest that the pathophysiology of impulsivity or disinhibition of the characteristic symptoms of ADHD boys is associated with hypoactivities of left orbitofrontal area and left caudate nucleus, and MPH pharmacodynamics in ADHD boys is associated to their actions on these two areas.
Methods : The rCBF of 5 boys with pure ADHD and 5 control boys were examined by Tc-99m ECD brain SPECT and cognitive characteristics by ADS and every 5 ADHD boys took MPH for 12 to 16 weeks. After that all ADHD boys took Tc-99m ECD brain SPECT and checked ADS again. rCBF difference and changes before and after MPH treatment were quantified and analyzed by using SPM. And, associations between types of cognitive changes measured by ADS and rCBF changes were examined, and quantitative associations between them were also analyzed by using Pearson's coefficient correlation.
Results : 1) Before MPH treatment, rCBF of ADHD boys were significantly decreased in left orbitofrontal area and left caudate nucleus compared to normal controls. 2) After MPH treatment, rCBF of the same regions were significantly increased. 3) There was positive correlation between the degree of commission error(impulsivity, disinhibition) among the ADS variables and the degree of blood-flow decrease in above two areas before MPH treatment but after MPH treatment, only with the degree of rCBF increase in Lt orbitofrontal area.
Conclusion : These results suggest that the pathophysiology of impulsivity or disinhibition of the characteristic symptoms of ADHD boys is associated with hypoactivities of left orbitofrontal area and left caudate nucleus, and MPH pharmacodynamics in ADHD boys is associated to their actions on these two areas.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
최근 본 자료 전체보기
UCI(KEPA) : I410-ECN-0101-2009-513-017219326
