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대한생물치료정신의학회 생물치료정신의학 생물치료정신의학 제10권 제1호
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피인용 4

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    초록·키워드

    Objectives : The purpose of this study is to evaluate the effects of 24 hours sleep deprivation on the psychophysiologic functions(daytime sleepiness, fatigue, mood, vigilance, attention and short-term memory) and then to examine whether caffeine ingestion improves the effects induced by sleep deprivation in healthy korean population.
    Methods : 16 healthy korean university students who didn't have psychiatric disorder or sleep disorder and complain sleep-wake cycle disturbance, carried out ESS(Epworth Sleepiness Scale), VAS(Visual Analogue Scale), MSLT, and Computerized Neurocognitive Function Test under following conditions ; after normal usual sleep(Baseline), after 24 hours sleep deprivation, and after 24 hours sleep deprivation followed by 150㎎ of caffeine ingestion.
    Results : After 24 hours sleep deprivation, the subjective and objective daytime sleepiness, fatigue and dysphoria were increased as compared to baseline, attention and vigilance were decreased compared to baseline and short-term memory wasn't significantly changed. When the subjects Ingested 150㎎ of caffeine after 24 hours sleep deprivation, an increment of subjective and objective daytime sleepiness, fatigue and dysphoria and a decrement of attention and vigilance induced in sleep deprivation was improved. 150㎎ of caffeine given after 24 hours sleep deprivation improved significantly the objective daytime sleepiness, attention, and vigilance to the baseline level, and also improved significantly the subjective daytime sleepiness, fatigue and dysphoria but didn't reach the baseline level.
    Conclusions : 24 hours sleep deprivation in the normal young adult increased the subjective and objective daytime sleepiness, fatigue and dysphoria and decreased attention and vigilance, whereas didn't develop short-term memory disturbance. Following caffeine ingestion improves an increased objective daytime sleepiness, a decreased attention, and a decreased vigilance induced in sleep deprivation to almost same degree of baseline, out doesn't improve an increased objective daytime sleepiness, fatigue and dysphoria induced sleep deprivation to same degree of baseline.

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      UCI(KEPA) : I410-ECN-0101-2009-513-017219442