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    It is demonstrated that cadmium has cytotoxic effect on glial cells, oxygen radicals are involved in cadmium-induced cytotoxicity. However, the toxic mechanism of cadmium is left unknown so far. The purpose of this study was to examine the cytotoxicity of CdCl<SUB>2</SUB> on C<SUB>6</SUB> glioma cells. The cytotoxicy was measured by cell viability via XTT assay in C<SUB>6</SUB> glioma cells. Colorimetric assay such as XTT assay is regarded as a very sensitive screening method for the determination of the cell viability on a lots of chemicals. In this study, CdCl<SUB>2</SUB> decreased cell viability according to the dose- and time dependent manners after C<SUB>6</SUB> glioma cells were treated with various concentrations of CdCl<SUB>2</SUB> for 48 hours. IC<SUB>90</SUB> and IC<SUB>50</SUB> values for XTT assay was determined at 5 μM and 55 μM of CdCl<SUB>2</SUB>, respectively. These results suggest that CdCl<SUB>2</SUB> has highly cytotoxic effect on C<SUB>6</SUB> glioma cells by the decrease of cell viability.

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      UCI(KEPA) : I410-ECN-0101-2009-510-017357404