지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.12
- 수록면
- 337 - 341 (5page)
이용수
초록· 키워드
오류제보하기
Platelets clearly play an important role in inflammatory responses. In this study, we aimed to evaluate the relationship between aging and platelet activation. A total number of 799 persons (383 males and 416 females), who were apparently healthy and aged more than 20 years were recruited by a health promotion center in a community-based hospital in Seoul, Korea. We collected material data about their medical history and health behavior. Platelet parameters including mean platelet component (MPC), mean platelet volume (MPV), and platelet component distribution width (PCDW) were determined within 1 hour after blood collection using the ADVIA 120 automated hematology analyzer. The MPC of the women (27.2±1.2) was significantly lower than that of the men (27.5±1.3). The MPC of all participants was found to decrease with increasing age (P＜0.01). Study participants in their twenties had the highest MPC (27.7±1.1), followed by those in their thirties (27.6±1.1), forties (27.4±1.3), fifties (27.2±1.3), sixties (27.2±1.2) and seventies (27.1±1.2). Multiple regression analysis showed that aging and gender were related with MPC after adjusting for confounding factors, including age, gender, smoking habit, hypertension, diabetes, body mass index and total cholesterol level. The this study shows that aging is related to platelet activation. Future research will need to determine the implications of increased platelet activation with aging, especially regarding the increased incidence of cardiovascular diseases and related mortalities that occur in older age groups.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Y,Ahmed / 1993 / Retrospective analysis of platelet number and volume in normal pregnancy and in pre-eclampsia / Br J Gynaecol. 100 : 216 ~ 220
2. [학술지(정기간행물)] - JL,Barnes / 1997 / Platelets in glomerular disease / Nephron 77 : 378 ~ 393
3. [학술지(정기간행물)] - A,Broijersen / 1998 / Platelet activity in vivo in hyperlipoproteinemia-importance of combined hyperlipidemia / Thromb Haemost. 79 : 268 ~ 275
4. [학술지(정기간행물)] - DR,Brummitt / 2000 / The determination of a reference range for new platelet parameters produced by the Bayer ADVIA TM 120 full blood count analysis / Clin Lab Heam. 22 : 102 ~ 107
5. [학술지(정기간행물)] - MR,Cahill / 1996 / Platelet surface activation antigen expression at baseline and during elective angioplasty in patients with mild to moderate coronary artery disease / Blood Coagul Fibrinol. 7 : 165 ~ 168
2. [학술지(정기간행물)] - JL,Barnes / 1997 / Platelets in glomerular disease / Nephron 77 : 378 ~ 393
3. [학술지(정기간행물)] - A,Broijersen / 1998 / Platelet activity in vivo in hyperlipoproteinemia-importance of combined hyperlipidemia / Thromb Haemost. 79 : 268 ~ 275
4. [학술지(정기간행물)] - DR,Brummitt / 2000 / The determination of a reference range for new platelet parameters produced by the Bayer ADVIA TM 120 full blood count analysis / Clin Lab Heam. 22 : 102 ~ 107
5. [학술지(정기간행물)] - MR,Cahill / 1996 / Platelet surface activation antigen expression at baseline and during elective angioplasty in patients with mild to moderate coronary artery disease / Blood Coagul Fibrinol. 7 : 165 ~ 168
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UCI(KEPA) : I410-ECN-0101-2009-510-017673909