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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.3
- 수록면
- 25 - 31 (7page)
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초록· 키워드
오류제보하기
To evaluate the protective effect of Houttuynia cordata on hydrogen peroxide-induced oxidative DNA damage in HepG2 cell line, we used an alkaline single-cell gel electrophoresis (SCGE; comet assay). The DNA damage was analyzed by tail moment (TM) and tail length (TL), which used markers of DNA strand breaks in SCGE. The 100 μg/ml of methanolic extract of Houttuynia cordata root showed significant protective effects (p ＜ 0.01) against hydrogen peroxide-induced DNA damage in HepG2 cells and increased cell viability against hydrogen peroxide. The results of this study indicate that Houttuynia cordota root methanol extract acts as a potential antioxidant, and exhibits potential anticancer properties, which may provide a clue to find applications in new pharmaceuticals for oxidative stability.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCE
참고문헌 (32)
참고문헌 신청
, 2001 , Resveratrol, a natural phenlic compound, inhibites cel proliferation and pre-vents oxidative DNA damage 496 : 171 ~ 180
, 1996 , Use of the alkaline comet assay to detect DNA repair deficiencies in human fibroblasts exposed to UVC, UVB, UVA and r-rays 59 : 359 ~ 369
, 1993 , antioxidants and degenerative disease of aging Proceeddings of the National Science of the UnitedStates of America : 7915 ~ 792
, 1994 , The effect of various antioxidants and other modi-fying agents on oxygen-radical-generated DNA damage inhuman lymphocytes in Comet assay : 30 261 ~ 271
, 1996 , An investigation of some Turkish herbal medi-cines in Salmonella typhimurium and in the Comet assay in human lymphocytes 16 : 125 ~ 138
, 1996 , Use of the alkaline comet assay to detect DNA repair deficiencies in human fibroblasts exposed to UVC, UVB, UVA and r-rays 59 : 359 ~ 369
, 1993 , antioxidants and degenerative disease of aging Proceeddings of the National Science of the UnitedStates of America : 7915 ~ 792
, 1994 , The effect of various antioxidants and other modi-fying agents on oxygen-radical-generated DNA damage inhuman lymphocytes in Comet assay : 30 261 ~ 271
, 1996 , An investigation of some Turkish herbal medi-cines in Salmonella typhimurium and in the Comet assay in human lymphocytes 16 : 125 ~ 138
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UCI(KEPA) : I410-ECN-0101-2009-513-016602074