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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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초록· 키워드
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Scutellaria baicalensis GEORGI (SB) is used in oriental medicine for the treatment of incipient strokes. Although it has been reported that SB is neuroprotective in a hypoxia model, its mechanism is poorly understood. Here, we investigated the effect of SB on the modulation of heme oxygenase-1 (HO-1), which has important biological roles in regulating mitochondrial heme protein turnover and in protecting against conditions such as hypoxia, neurodegenerative diseases, or sepsis. Rat cerebrocortical day In vitro(DIV)12 cells were grown in neurobasal medium. On DIV12 cells were treated with SB (20 ㎍/㎖) and given a hypoxic shock (2% O₂/5% CO₂, 3 hr) on DIV14. In situ hybridization results revealed that SB up regulated HO-1 mRNA in neuronal dendrites in both normoxia and hypoxia (38.5% and 59.2%, respectively). At the protein level, SB upregulated HO-1 in the neuronal soma in both normoxia and hypoxia (22.4% and 15.7%, respectively). Interestingly, most significant increase was associated with astrocytes, which increased HO-1 protein by 77.5% compared to SB-untreated culture. These results indicate that SB upregulates both neuronal and glial HO-1 expression, which contributes to the neuroprotection efficacy in hypoxia).
목차
서론
재료 및 방법
결과
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참고문헌
참고문헌 (58)
참고문헌 신청
Beschorner, R., D. Adjodah, J. M. Schilalo, M. Mittelbronn, I. Pedal, R. Mattern, H. J. Schluesener and R. Meyermann. 2000. Long-term expression of heme oxygenase-1 (HO-1, HSP 32) following focal cerebral infarctions and traumatic brain injury in human. A
Bickler, P. E. and P. H. Donohoe. 2002. Adaptive responses of vertebrate neurons to hypoxia. J. Exp. Biol. 205, 3579-3586.
Brewer, G. J., J. R. Torricelli, E. K. Evege and P. J. Price. 1993. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J. Neurosci. Res. 35, 567-576.
Burmester, T. and T. Hankeln. 2004. Neuroglobin: a respiratory protein of the nervous system. News Physiol Sci. 19, 110-113.
Cai, J. and D. P. Jones. 1998. Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss. J. Biol. Chem. 273, 114001-114014.
Bickler, P. E. and P. H. Donohoe. 2002. Adaptive responses of vertebrate neurons to hypoxia. J. Exp. Biol. 205, 3579-3586.
Brewer, G. J., J. R. Torricelli, E. K. Evege and P. J. Price. 1993. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J. Neurosci. Res. 35, 567-576.
Burmester, T. and T. Hankeln. 2004. Neuroglobin: a respiratory protein of the nervous system. News Physiol Sci. 19, 110-113.
Cai, J. and D. P. Jones. 1998. Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss. J. Biol. Chem. 273, 114001-114014.
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UCI(KEPA) : I410-ECN-0101-2009-470-016676332