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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2006.11
- 수록면
- 6 - 11 (6page)
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초록· 키워드
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The aggregation characteristics of red blood cells (RBCs) play an important role in microvascular flow system and increased RBC aggregation has been observed in various pathological diseases, such as thrombosis and myocardial infarction. This paper presents a novel microfluidic device for evaluating the aggregability of RBCs on the flow of blood by directly measuring aggregating force (critical shear stress) to overcome shearing force due to flow in a microchannel. The device functionality is based on a microfluidic slit rheometry with decreasing pressure-driven flow mechanism with laser light backscattering technique. The present RBC aggregation index shows a higher sensitivity to small changes of aggregation modulated by amount of fibrinogen in blood plasma. The direct measurement of RBC aggregating force represents a new concept for the field of blood rheology and should prove beneficial for basic science and clinical applications.
목차
Abstract
1. Introduction
2. Experiment
3. Conclusions
4. Acknowledgments
References
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UCI(KEPA) : I410-ECN-0101-2009-550-016802811