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초록· 키워드
Background - In this paper, we present evidence that the Korean red ginseng extract shows the immunomodulatory activities during postoperative chemotherapy after curative surgery in patients with advanced colon cancer. We measured the circulating interleukin-2(IL-2), interleukin-8(IL-8)and interleukin-10(IL-10) as a immune modulator to evaluate the effect of Korean red ginseng.
Material & Method - From July, 2005 to February, 2006,total 47 of the advances colon cancer patient who underwent the curative surgery at Korea University Hospital were enrolled. 24 of colorectal carcinoma patients were assigned to non-red ginseng (non-RG) group that would not be treated with red ginseng extract. And 23 of colorectal carcinoma patients were assigned to red ginseng(RG) group. All of them was treated with 5-fluouracil +leukovorin chemotherapy after curative surgery for 6 months. We treated RG group patient with 3 g/day of red ginseng extract(Korea Ginseng Corporation, Seoul, Korea) for 3 months. IL-2, IL-8 and IL-10 were evaluated at preoperative day, postoperative months I and 3 from peripheral circulating blood draws. The value was analysed with ELISA test.
Result - The mean preoperative value of IL-2 was similar in the non-RG group and the RG group(5.72 pg/㎖ versus 6.87 pg/㎖, p＞0.05). The mean value of IL-2 was compared with IL-2 from healthy control group, there was no significant difference(14.89 pg/㎖ versus 14.22 pg/㎖, p＞0.05). The mean preoperative value of IL-8 was higher in the non-RG group comparing with the RG group (30.92 pg/㎖ versus 36.25 pg/㎖, p＜0.05). At postoperative 3 month, the mean values of IL-8 from non-RG and RG group down to 24.56 pg/㎖ and 21.46 pg/㎖ respectively. The IL-8 of RG group at 3 month showed no difference with that of HC group(21.46 pg/㎖ versus 16.31 pg/㎖, p＞0.05). The preoperative mean value of IL-10 of non-RG, RG and HC group was 11.56 pg/㎖, 10.8 pg/㎖, and 3.68 pg/㎖ respectively. At postoperative 3 month, the mean values of IL-10 from non-RG and RG group down to 8.45 pg/㎖ and 5.04 pg/㎖ respectively. In spite of decreasing IL-10 levels of both cancer patients group with time, there was still significant difference with that of HC group (non-RG versus HC group, p=0.00, RG versus HC group, p=0.04).
Conlusion - The results of this study suggest that the red ginseng extract may have some immunomodulatory properties associated with IL-2, IL-8 and IL-10 activity in patients with advanced colorectal cancer during postoperative chemotherapy. We think to need the further studies and a larger sample size to fully evaluate the antitumor effect of ginseng and need to establish this mechanism of action as well as identify the active components associated with antitumor activity and immunomodulation in patients with advanced colorectal cancer.
상세정보 수정요청해당 페이지 내 제목·저자·목차·페이지Material & Method - From July, 2005 to February, 2006,total 47 of the advances colon cancer patient who underwent the curative surgery at Korea University Hospital were enrolled. 24 of colorectal carcinoma patients were assigned to non-red ginseng (non-RG) group that would not be treated with red ginseng extract. And 23 of colorectal carcinoma patients were assigned to red ginseng(RG) group. All of them was treated with 5-fluouracil +leukovorin chemotherapy after curative surgery for 6 months. We treated RG group patient with 3 g/day of red ginseng extract(Korea Ginseng Corporation, Seoul, Korea) for 3 months. IL-2, IL-8 and IL-10 were evaluated at preoperative day, postoperative months I and 3 from peripheral circulating blood draws. The value was analysed with ELISA test.
Result - The mean preoperative value of IL-2 was similar in the non-RG group and the RG group(5.72 pg/㎖ versus 6.87 pg/㎖, p＞0.05). The mean value of IL-2 was compared with IL-2 from healthy control group, there was no significant difference(14.89 pg/㎖ versus 14.22 pg/㎖, p＞0.05). The mean preoperative value of IL-8 was higher in the non-RG group comparing with the RG group (30.92 pg/㎖ versus 36.25 pg/㎖, p＜0.05). At postoperative 3 month, the mean values of IL-8 from non-RG and RG group down to 24.56 pg/㎖ and 21.46 pg/㎖ respectively. The IL-8 of RG group at 3 month showed no difference with that of HC group(21.46 pg/㎖ versus 16.31 pg/㎖, p＞0.05). The preoperative mean value of IL-10 of non-RG, RG and HC group was 11.56 pg/㎖, 10.8 pg/㎖, and 3.68 pg/㎖ respectively. At postoperative 3 month, the mean values of IL-10 from non-RG and RG group down to 8.45 pg/㎖ and 5.04 pg/㎖ respectively. In spite of decreasing IL-10 levels of both cancer patients group with time, there was still significant difference with that of HC group (non-RG versus HC group, p=0.00, RG versus HC group, p=0.04).
Conlusion - The results of this study suggest that the red ginseng extract may have some immunomodulatory properties associated with IL-2, IL-8 and IL-10 activity in patients with advanced colorectal cancer during postoperative chemotherapy. We think to need the further studies and a larger sample size to fully evaluate the antitumor effect of ginseng and need to establish this mechanism of action as well as identify the active components associated with antitumor activity and immunomodulation in patients with advanced colorectal cancer.
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목차
- Abstract
- 1. Introduction
- 2. Subjects and Method
- 3. Results
- 4. Discussion
- Acknowledgments
- References
- 인삼학회 30년
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UCI(KEPA) : I410-ECN-0101-2009-524-016168563
