인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
The purpose of this study is to investigate a potential toxicity of licorice root (LR) in Fisher 344 rats through the 13-week repeated oral treatment. Healthy Fisher 344 rats were divided into five treatment groups (2,000, 571, 163, 47, and 13 ㎎/㎏) and one control group (vehicle) of 12 males and 12 females respectively. LR was orally administered by gavage to F344 rats once a day, 5 days per week for 13 weeks. During the test period, clinical signs, mortality, body weights, necropsy findings, hematology, serum biochemistry, organ weight, histopathology, sperm count and sperm motility were evaluated. The relative liver weights were increased significantly in males of the 2,000 and 571 ㎎/㎏ groups. However, there was no histological evidence in the liver. The increased incidence of chronic nephropathy only appeared in the 2,000 ㎎/㎏ group of both male and female rats. There were no treatment-related effects on clinical signs, mortality, body weights, necropsy findings, hematology, serum biochemistry and sperm count and motility in any treatment groups. Based on these results, no-observed adverse effect level (NOAEL) of LR was 571 ㎎/㎏ in F344 rats under the conditions of the present study.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
최근 본 자료 전체보기
UCI(KEPA) : I410-ECN-0101-2009-510-016362676
