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    Understanding of bacteriophage kinetics in mammals or higher organisms is needed, as this determines the potential phage activity in antibacterial treatment. We demonstrated the fate and survivability of fish phage particles in different organs and fluids inoculated into mice. Phage (PPpW-4) specific to Pseudomonas plecoglossicida was intraperitoneally injected to mice with a dose of 10<SUP>8.1</SUP> PFU/㎖/mouse. Phage titers (10<SUP>3.0</SUP>~10<SUP>5.2</SUP> PFU/g) were detected in blood and other organs within 10 min after injection except in the urine samples. Phage titers in blood (10<SUP>5.1</SUP>~10<SUP>6.9</SUP> PFU/g) were 10~100 times higher than that of the other ... 전체 초록 보기

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      UCI(KEPA) : I410-ECN-0101-2009-510-016363259