인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Although the mechanism of stress-induced gastric ulcer has not been defined yet, it is clear that gastric ulcer is occurred by stress. Moreover, the gastric ulcerogenic action of corticosteroids that increase in blood during stress is controversial. To elucidate the involvement of corticosteroids in stress-induced gastric ulceration, we used adrenalectomized or macrophage-depleted animals. Rats were bilaterally-adrenalectomized and were given saline solution as a drinking water for 6 days. Separately, the animals for macrophage depletion were intraperitoneally administered with silica (SiO₂, 500 ㎎/㎏) for 6 days prior to challenge with water-immersion restraint stress (WIRS) for 4 hr. Adrenalectomy greatly reduced blood cortisol concentrations. Also, silica treatment lowered the number of macrophages to 48% of control and the differential count from 7.34% in normal animals to 2.48%, leading to a marked decrease in blood cortisol and corticosterone levels. WIRS significantly enhanced corticosteroid levels in normal and sham operated rats, and induced severe gastric ulcers. In contrast, adrenalectomy and silica treatment remarkably attenuated the stress-induced gastric ulceration, reducing the ulcer index to 30% and 10% of control level, respectively. Taken together, it is suggested that compensatory secretion of corticosteroids following macrophage activation may playa role in stress-induced gastric ulceration.
본문·목차
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
최근 본 자료 전체보기
UCI(KEPA) : I410-ECN-0101-2009-510-016363320
