지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.9
- 수록면
- 285 - 288 (4page)
이용수
초록· 키워드
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Chronic Helicobacter pylori (H. pylon) infection has an estimated world wide incidence of 50% and it has been associated with the pathogenesis of gastroduodenal diseases namely chronic gastritis, peptic ulcer, MALT lymphoma and gastric cancer. Apoptosis is related with cell death and oncogenesis. Two kinds of gastric cell lines (mucous and parietal cells) were exposed with water extract of H. pylori (HPE) of previously defined VacA, urease, CagE and CagA status. The mouse gastric parietal cell line MGE507 and gastric epithelial cell line GSMO6 cells were cultured and used to study the difference of apoptotic expression against HPE. The expression of apotosis was evaluated in two cell lines. Both mucous and parietal cell lines induced caspase-3-dependent apoptosis by HPE. However, the expressed amounts were higher in parietal cells than mucous cells. It is concluded that apoptosis is expressed strongly by parietal cells following H. pylori infection. On our knowledge, this is the first report about the apoptosis expression of gastric parietal cells by H. pylori infection.
목차
Material and Methods
Results
Discussion
Acknowledgment
References
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Buck / 1986 / Relation of Campylobacter pyloridis to gastritis and peptic ulcer. J. Infect. Dis. 153
2. [학술지(정기간행물)] - Castano, A / 2000 / The use of alternative systems for the ecotoxicological screening of complex mixtures on fish populations 247 : 337 ~ 348
3. [학술지(정기간행물)] - Combes, R.D / 2005 / Assessing risk to humans from chemical exposure by using non-animal test data 19 : 921 ~ 924
4. [학술지(정기간행물)] - Cover, T.L / 2003 / Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin 63 : 951 ~ 957
5. [학술지(정기간행물)] - Fiocca, R / 1999 / Release of Helicobacter pylori vacuolating cytotoxin by both a specific secretion pathway and budding of outer membrane vesicles. Uptake of released toxin and vesicles by gastric epithelium 188 : 220 ~ 226
2. [학술지(정기간행물)] - Castano, A / 2000 / The use of alternative systems for the ecotoxicological screening of complex mixtures on fish populations 247 : 337 ~ 348
3. [학술지(정기간행물)] - Combes, R.D / 2005 / Assessing risk to humans from chemical exposure by using non-animal test data 19 : 921 ~ 924
4. [학술지(정기간행물)] - Cover, T.L / 2003 / Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin 63 : 951 ~ 957
5. [학술지(정기간행물)] - Fiocca, R / 1999 / Release of Helicobacter pylori vacuolating cytotoxin by both a specific secretion pathway and budding of outer membrane vesicles. Uptake of released toxin and vesicles by gastric epithelium 188 : 220 ~ 226
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UCI(KEPA) : I410-ECN-0101-2009-510-016364241