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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2006.4
- 수록면
- 19 - 29 (11page)
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Influenza A virus infection causes substantial annual morbidity and mortality worldwide, particularly for infants, the elderly, and the immunocompromised. A growing concern is the recent identification of H5N1 subtypes of avian influenza A in Asia that were previously thought to infect only wild birds and poultry, but have now infected humans, cats, pigs, and other mammals, often with fatal results, in an ongoing outbreak. A human pandemic with H5N1 virus could potentially be catastrophic because most human populations have negligible antibody-mediated immunity to the H5 surface protein and this viral subtype is highly virulent.
Vaccination is the effective means to control the impact of influenza. The 2004 Asian H5N1 epizootic outbreak indicates the urgent need for vaccines against avian influenza viruses. Some influenza antiviral drugs are available for early treatment and prophylaxis of influenza for human only. Neuraminidase inhibitors, such as zanamivir and oseltamivir, are effective in prevention studies and are highly active against a broad range of influenza A viruses of both human and avian origin, including amantadin-resistant strains. However, there are no available agents for early treatment and prophylaxis of influenza to control current avian influenza endemics in domestic and wild birds. The commercially available inactivated avian influenza vaccines are effective for preventing clinical signs and death but not effective for preventing infection. Therefore, alternative prophylactic and/or therapeutic methods are required to human as well as animals.
To prevent and treat influenza viruses, many kinds of antiviral drugs are developing. There is great interest in the identification of novel antiviral agents from chemical and natural compounds. Recent efforts for developing antiviral therapy for avian influenza will be discussed.
Vaccination is the effective means to control the impact of influenza. The 2004 Asian H5N1 epizootic outbreak indicates the urgent need for vaccines against avian influenza viruses. Some influenza antiviral drugs are available for early treatment and prophylaxis of influenza for human only. Neuraminidase inhibitors, such as zanamivir and oseltamivir, are effective in prevention studies and are highly active against a broad range of influenza A viruses of both human and avian origin, including amantadin-resistant strains. However, there are no available agents for early treatment and prophylaxis of influenza to control current avian influenza endemics in domestic and wild birds. The commercially available inactivated avian influenza vaccines are effective for preventing clinical signs and death but not effective for preventing infection. Therefore, alternative prophylactic and/or therapeutic methods are required to human as well as animals.
To prevent and treat influenza viruses, many kinds of antiviral drugs are developing. There is great interest in the identification of novel antiviral agents from chemical and natural compounds. Recent efforts for developing antiviral therapy for avian influenza will be discussed.
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UCI(KEPA) : I410-ECN-0101-2009-510-016369120