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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2006.11
- 수록면
- 87 - 105 (19page)
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The purpose of this study was to determine the adverse effects of methylmercuric chloride(MMC) against the fetal growth and the ossification rate of fetal pectoral and pelvic girdle, sternebrae, ribs and tail in pregnant Fischer 344 rats administered orally on day 7 of gestation. The resulted obtained are as follows.
The weight and size of fetus were highly reduced by MMC. The reduction of fetal weight and size were 16.2% ~ 24.5%(p＜0.01), and 34.1% ~ 48.8%(p＜0.01), and that of the litter's weight were 67.0%(p＜0.01) and 89.2%(p＜0.01) by 20 and 30 ㎎/㎏ MMC, respectively.
Ossification centers were never formed in pectoral and pelvic phalanges and sternebrae, and was reduced as much as 70% in tail by 30 ㎎/㎏ MMC. Reduction of ossification rate was also very higher in MMC groups than control one. The reduction of ossification rate were 47.5% ~ 58.3%(p＜0.01) in metacarpals, and 34.5% ~ 44.2%(p＜0.01) in the others(clavicle, scapule, humerus, radius, ulna) of pectoral girdle by 30 ㎎/㎏ MMC. And also those were 82.4% ~ 91.2%(p＜0.01) in ischium, and 52.4 ~ 66. 7%(p＜0.01) in the others (ilium, femur, tibia, fibula, metatarsals) of pelvic girdle by 30 ㎎/㎏ MMC. Ossification of sternebrae was terrible. 5th bone of sternebrae was not ossificated by 20 and 30 ㎎/㎏ MMC(p＜0.01), and 2nd was also not ossificated by 30 ㎎/㎏ MMC(p＜0.01). And reduction of ossification rate was 84.8 ~ 97.8%(p＜0.01) in the others of sternebrae by 30 ㎎/㎏ MMC. And then, the reduction of ossification rate was 26.6 ~ 49.8%(p＜0.01) in fetal ribs by 30 ㎎/㎏ MMC, and they were trend to increased as following from center to each edge.
In conclusion, it was observed that fetal weight, size, and ossification of each bone were highly significantly reduced by the increased dosage of MMC.
The weight and size of fetus were highly reduced by MMC. The reduction of fetal weight and size were 16.2% ~ 24.5%(p＜0.01), and 34.1% ~ 48.8%(p＜0.01), and that of the litter's weight were 67.0%(p＜0.01) and 89.2%(p＜0.01) by 20 and 30 ㎎/㎏ MMC, respectively.
Ossification centers were never formed in pectoral and pelvic phalanges and sternebrae, and was reduced as much as 70% in tail by 30 ㎎/㎏ MMC. Reduction of ossification rate was also very higher in MMC groups than control one. The reduction of ossification rate were 47.5% ~ 58.3%(p＜0.01) in metacarpals, and 34.5% ~ 44.2%(p＜0.01) in the others(clavicle, scapule, humerus, radius, ulna) of pectoral girdle by 30 ㎎/㎏ MMC. And also those were 82.4% ~ 91.2%(p＜0.01) in ischium, and 52.4 ~ 66. 7%(p＜0.01) in the others (ilium, femur, tibia, fibula, metatarsals) of pelvic girdle by 30 ㎎/㎏ MMC. Ossification of sternebrae was terrible. 5th bone of sternebrae was not ossificated by 20 and 30 ㎎/㎏ MMC(p＜0.01), and 2nd was also not ossificated by 30 ㎎/㎏ MMC(p＜0.01). And reduction of ossification rate was 84.8 ~ 97.8%(p＜0.01) in the others of sternebrae by 30 ㎎/㎏ MMC. And then, the reduction of ossification rate was 26.6 ~ 49.8%(p＜0.01) in fetal ribs by 30 ㎎/㎏ MMC, and they were trend to increased as following from center to each edge.
In conclusion, it was observed that fetal weight, size, and ossification of each bone were highly significantly reduced by the increased dosage of MMC.
목차
Abstract
Ⅰ. 서론
Ⅱ. 실험 재료 및 방법
Ⅲ. 실험결과
Ⅳ. 고찰
Ⅴ. 결론
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UCI(KEPA) : I410-ECN-0101-2009-517-016425048