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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.6
- 수록면
- 173 - 178 (6page)
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An acidic polysaccharide of Panax ginseng (APG), so called ginsan, is known to have important immunomodulatory activities. It was recently reported that APG had radioprotective effects in mice but the detailed mechanism was not fully elucidated. We investigated the potential of APG to protect the hematopoietic and immune systems of mice from radiation injury by a single whole-body irradiation (WBI) in vivo. From our results, the counts of endogenous colony forming units (CFUs) increased in APGtreated mice, indicating that APG induced the regeneration of hematopoietic cells. In splenocytes, APG treatment decreased the percent of tail DNA, a parameter of DNA damage, and also accelerated the proliferation and recovery of splenocytes, compared with untreated, irradiated controls. Furthermore, the number of apoptotic cells was significantly decreased in splenocytes of APG-treated mice compared with that of irradiated controls. Overall, this study shows that APG can enhance the regeneration of hematopoietic stem cells, and promote the repair of damaged cells or the proliferation of the immune cells. Therefore, our current data provide evidence that APG can have radioprotective effects on hematopoietic and immune systems in vivo.
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감사의 글
참고문헌
참고문헌 (24)
참고문헌 신청
Arora, R , 2005 , Radioprotection by plant products: present status and future prospects , Phytother. Res 19 : 1 ~ 22
Ahn, J.Y , 2006 , The immunomodulator ginsan induces resistance to experimental sepsis by inhibiting Toll-like receptor-mediated inflammatory signals , Eur. J. Immunol 36 : 37 ~ 45
Cairnie, A.B , 1983 , Adverse effects of radioprotector WR2721 , Radiat. Res 94 : 221 ~ 226
Choi, S.S , 2003 , Effect of ginsenosides administered intrathecally on the antinociception induced by cold water swimming stress in the mouse , Biol. Pharm. Bull 26 : 858 ~ 861
Choo, M.K , 2003 , Antiallergic activity of ginseng and its ginsenoside , Planta Med 69 : 518 ~ 522
Ahn, J.Y , 2006 , The immunomodulator ginsan induces resistance to experimental sepsis by inhibiting Toll-like receptor-mediated inflammatory signals , Eur. J. Immunol 36 : 37 ~ 45
Cairnie, A.B , 1983 , Adverse effects of radioprotector WR2721 , Radiat. Res 94 : 221 ~ 226
Choi, S.S , 2003 , Effect of ginsenosides administered intrathecally on the antinociception induced by cold water swimming stress in the mouse , Biol. Pharm. Bull 26 : 858 ~ 861
Choo, M.K , 2003 , Antiallergic activity of ginseng and its ginsenoside , Planta Med 69 : 518 ~ 522
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