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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.6
- 수록면
- 107 - 113 (7page)
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초록· 키워드
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In this study, we have investigated the effect of panaxatriol (PT) on phosphoinositides (PIS) breakdown and Ca<SUP>2+</SUP>-elevation in thrombin-induced platelet aggregation. Thrombin (5U/ml), a potent platelet agonist which activates phospholipase C<SUB>β</SUB> via protease activated receptor (PAR), hydrolyzed PIS in platelet membrane. The phosphatidylinositol 4, 5-bisphosphate (PIP₂) was hydrolyzed after 10 sec of the thrombin-stimulation, and both the phosphatidylinositol 4-monophosphate (PIP) and phosphatidylinositol (PI) were brokendown after 30 sec of the thrombin-stimulation. However, PT inhibited the thrombin-stimulated hydrolysis of PIP₂, PIP, and PI. On the other hand, thrombin increased the level of phosphatidic acid (PA) which is phosphorylated from diacylglycerol (DG) generated by PIS-hydrolysis. However, PT inhibited the thrombin-increased PA level non-significantly. Thrombin increased cytosolic free Ca<SUP>2+</SUP>[Ca<SUP>2+</SUP>]<SUB>i</SUB>) up to 72% as compared with control (30.8±0.9 nM) in intact platelet. However, PT (100 ㎍/ml) inhibited the thrombin-elevated [Ca<SUP>2+</SUP>]<SUB>i</SUB> to 100%. These results suggest that PT may have a beneficial effect on platelet aggregation-mediated thrombotic disease by inhibiting thrombin-induced platelet aggregation via suppression of the [Ca<SUP>2+</SUP>]<SUB>i</SUB> level and PIS breakdown.
목차
Abstracts
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENT
REFERENCES
참고문헌 (25)
참고문헌 신청
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Berridge, M. J. , 1984 , Inositol trisphosphate, a novel second messenger in cellular signal transduction , Nature 312 : 315 ~ 321
Majerus, P. W. , 1984 , Production of phosphoinositide-derived messenger , Cell 37 : 701 ~ 703
Nishizuka, Y. , 1984 , The role of protein kinase C in cell surface signal transduction and tumor promotion , Nature 308 : 693 ~ 697
Nishikawa, M. , 1980 , Ca2+-calmodulindependent phosphorylation and platelet secretion , Nature 287 : 863 ~ 865
Berridge, M. J. , 1984 , Inositol trisphosphate, a novel second messenger in cellular signal transduction , Nature 312 : 315 ~ 321
Majerus, P. W. , 1984 , Production of phosphoinositide-derived messenger , Cell 37 : 701 ~ 703
Nishizuka, Y. , 1984 , The role of protein kinase C in cell surface signal transduction and tumor promotion , Nature 308 : 693 ~ 697
Nishikawa, M. , 1980 , Ca2+-calmodulindependent phosphorylation and platelet secretion , Nature 287 : 863 ~ 865
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Panax ginseng C. A. Meyer의 PD와 PT는 아드레날린에 의해 유인된 사람 혈소판의 응집반응에서 Thromboxane A_2_ 의 생성을 저해한다 ( Panaxadiol and Panaxatriol from Panax ginseng C. A. Meyer Inhibit the Synthesis of Thromboxane A_2_ in Adrenalin-Stimulated Human Platelet Aggregations )
Journal of Ginseng Research
1994 .04
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벤젠 에틸렌 수지 흡착에 의한 인삼의 Panaxadiol과 Panaxatriol의 신속한 분리 ( A Rapid Separation of an Edible Panaxadiol and Panaxatriol in Ginseng Saponins by Benzene Ethylene Resin adsorption )
Journal of Ginseng Research
1998 .09
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한국 인삼과 타국 인삼의 성분 비교 연구
약학회지
1978 .01
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Breeding of Korean Ginseng ( Panax ginseng C. A. Meyer )
International Symposium on Ginseng
1998 .09
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혈소판 응집반응을 억제시키는 Panax ginseng C. A. Meyer의 비사포닌 분획 ( Non-Saponin Fraction from Panax ginseng C. A. Meyer Inhibits Platelet Aggregation )
Journal of Ginseng Research
1993 .12
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Study on the Response of Korean Ginseng ( Panax ginseng C. A. Meyer ) to the Herbicide 2,4-D Application
International Symposium on Ginseng
1990 .07
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(20R)-파낙사디올과 (20R)-파낙사트리올에 대한 $^1H$- 및 $^{13}C-NMR$의 완전동정
약학회지
1996 .01
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The Characterization of Mitochondrial DNA of Korean Ginseng ( Panax ginseng C. A. Meyer )
International Symposium on Ginseng
1990 .07
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Functional and comparative genomic analysis of the Panax ginseng C. A. Meyer
고려인삼학회 학술대회
2010 .05
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고려인삼 ( Panax ginseng C. A. Meyer ) 의 엽록체 DNA 분리 및 특성조사 ( Isolation and Characterization of Chloroplast DNA in Korean Ginseng , Panax ginseng C. A. Meyer )
Journal of Ginseng Research
1993 .04
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Inhibitory effects of total saponin from Korean red ginseng via vasodilator-stimulated phosphoprotein-Ser157 phosphorylation on thrombin-induced platelet aggregation
Journal of Ginseng Research
2013 .04
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Phosphoinositide 3-Kinase is necessary for ATX-induced tumor cell motility in human melanoma cells
한국실험동물학회 학술발표대회 논문집
2002 .06
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Glucocorticoid Receptor Induced Down Regulation of Metalloproteinase-9 ( MMP-9 ) by Ginseng Components , Ppanxadiol ( PD ) and Panaxatriol ( PT ) , Contributes to Inhibition of the Invasive Capacity of HT1080 Human Fibrosarcoma Cells
International Symposium on Ginseng
1998 .09
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LB30057 Inhibits Platelet Aggregation and Vascular Relaxation Induced by Thrombin
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2002 .01
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류마티스 관절염 환자의 말초혈액 단핵세포에서 Phosphoinositide 3-Kinase (PI3K)/Akt와 Nuclear Factor KappaB (NF-κB) 신호전달을 통한 IL-17 생성조절
Immune Network
2003 .12
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인삼 ( Panax ginseng C. A. Meyer ) Saponin분획의 생화학적 효과 ( Some Biochemical Effects of Saponin Fraction of Panax ginseng C. A. Meyer )
Journal of Ginseng Research
1992 .04
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고려인삼 ( Panax ginseng C. A. Meyer ) 의 년차간 형질상관 및 경로계수 분석 ( The Correlation of Agronomic Characters and Path Coefficient Analysis in Panax ginseng C. A. Meyer )
Journal of Ginseng Research
1995 .08
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Influence of Panaxatriol-type Saponin on Secretion of Catecholamines from Isolated Perfused Rabbit Adrenal Gland
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1989 .01
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