지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.9
- 수록면
- 244 - 249 (6page)
이용수
초록· 키워드
오류제보하기
Vascular inflammation is an important step in the development of cardiovascular disorder. Since it has not been known whether Korean red ginseng has a role to play on the vascular inflammation, we investigated the effects of Korean red ginseng extract (KRGE) on monocyte adhesion and its underlying signaling mechanism. Monocyte adhesion assay and Western blot were conducted on the human umbilical vein endothelial cells to study monocyte adhesion and the expression of adhesion molecules. Intracellular calcium was measured with Fura-2 fluorescent staining, and superoxide production was measured with lucigenin chemiluminescence in the endothelial cells. KRGE inhibits tumor necrosis factor (TNF)-alpha-induced monocyte adhesion on the endothelial cells at the range of 0.03~1 ㎎/㎖. TNF-alpha-induced vascular cell adhesion molecule-1 and intercellular cell adhesion molecule-1 expression were inhibited by the pretreatment of KRGE in the endothelial cells. KRGE also inhibits TNF-alpha-induced intracellular calcium and the superoxide production in the endothelial cells. This study first demonstrated that KRGE inhibits TNF-alpha-induced monocyte adhesion by inhibiting the adhesion molecule expression, intracellular calcium and superoxide production in the endothelial cells. Therefore, the anti-inflammatory function of KRGE may be contributed to protecting the endothelial dysfunction in the vascular inflammatory disorders.
목차
Abstracts
INTRODUCTION
MATERIAL AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGMENTS
REFERENCES
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Ross, R. / 1999 / Atherosclerosis-an inflammatory disease / N Engl J Med 340 : 115 ~ 126
2. [학술지(정기간행물)] - Ross, R. / 1995 / Cell biology of atherosclerosis / Annu Rev Physiol 57 : 791 ~ 804
3. [학술지(정기간행물)] - Lin, S. J. / 2005 / Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK/p38 pathways / Arterioscler Thromb Vasc Biol 25 : 334 ~ 340
4. [학술지(정기간행물)] - Irani, K. / 2000 / Oxidant signaling in vascular cell growth, death, and survival : a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling / Circ Res 87 : 179 ~ 183
5. [학술지(정기간행물)] - Jung, N. P. / 1996 / Studies on the physiological and biochemical effects of Korean ginseng / Kor J Ginseng Sci 20 : 431 ~ 471
2. [학술지(정기간행물)] - Ross, R. / 1995 / Cell biology of atherosclerosis / Annu Rev Physiol 57 : 791 ~ 804
3. [학술지(정기간행물)] - Lin, S. J. / 2005 / Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK/p38 pathways / Arterioscler Thromb Vasc Biol 25 : 334 ~ 340
4. [학술지(정기간행물)] - Irani, K. / 2000 / Oxidant signaling in vascular cell growth, death, and survival : a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling / Circ Res 87 : 179 ~ 183
5. [학술지(정기간행물)] - Jung, N. P. / 1996 / Studies on the physiological and biochemical effects of Korean ginseng / Kor J Ginseng Sci 20 : 431 ~ 471
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