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초록·키워드
Carnosine is a dipeptide (β-alanyl-L-histidine) found in mammalian skeletal muscle at high concentrations. Its biological functions in the muscle include antioxidant and buffering activities. The aim of this study was to evaluate the effect of carnosine on treadmill exercise capacity in mice. Fifty-six male ICR mice were divided into four groups including the control (vehicle) and oral carnosine-treated groups at the doses of 5, 50, and 500 ㎎/㎏/day for 4 weeks. All mice were acclimated to treadmill exercise for 4 weeks by running at 20-40 ㎝/sec for 10-30 min/day. At 2 and 4 weeks, endurance running time was measured. After 4 week, the activities of citrate synthase (CS), lactate dehydrogenase (LDH), and superoxide dismutase (SOD) were determined in gatrocnemius and soleus muscles. At 2 weeks after treatments, the endurance running time in the carnosine-treated groups (50 and 500 ㎎/㎏) was significantly shorter than those in the control group (P＜0.05). However, there were no statistically differences in endurance running time at 4 weeks between the control and carnosine-treated groups. CS activity was not markedly different between the control and the carnosine-treated groups. LDH activity was significantly reduced in the carnosine-treated group (500 ㎎/㎏). SOD activity was also significantly reduced in the carnosinetreated groups (50 and 500 ㎎/㎏). These results indicate that carnosine may decrease the exercise capacity in certain physiological conditions.
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UCI(KEPA) : I410-ECN-0101-2009-510-015707126
