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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.6
- 수록면
- 138 - 145 (8page)
이용수
초록· 키워드
오류제보하기
Objectives: The study was performed to investigate the changes of urinary thiodiglycolic acid (TDGA) concentration in workers exposed to vinyl chloride monomer (VCM) according to the time of sampling urine.
Methods: The personal exposure to airborne VCM was assessed and urinary TDGA concentration was sampled in 31 workers employed in a VCM and polyvinyl chloride (PVC) manufacturing factory. Urinary TDGA was sampled three times: before the start of the shift after 3 days off (TDGA1), after the end of the first-day shift (TDGA2) and before starting the following day shift after completing the one-day shift (TDGA3). Urinary TDGA in 30 workers who had not been exposed to airborne VCM was sampled after the end of the shift. A gas chromatography/pulsed flame photometric detector (GC/PFPD) was utilized to analyze TDGA concentration in urine after the urine was methylated with trimethylsilyldia-zomethane (2.0M in diethyl ether).
Results: The creatinine level was 0.179±0.271 ㎎/g in the control workers and 0.218±0.443 ㎎/g in the workers before the start of the shift after 3 days off (TDGA1), showing no significant difference (p=0.7035). Urine samples were compared according to sampling time in order to investigate the change of urinary TDGA concentration in the case of continuous exposure to airborne VCM. In VCM-exposed workers, urinary creatinine concentration was 0.434±0.623 mg/g in TDGA2 and 0.767±1.056 ㎎/g in TDGA3, which indicated a gradual but significant increase (p=0.024). In terms of the statistical correlation between airborne VCM and urinary TDGA to evaluate exposure dose per day, of the three urinary TDGA concentrations, TDGA3 showed the highest degree of regression (R2=0.4215) with 8h-TWA airborne VCM concentration.
Conclusion: Based on this result, the excretion half-life of urinary TDGA was assumed to be less than 3 days, because the concentration of urinary TDGA at 3 days after exposure to airborne VCM was decreased to the level of urinary TDGA concentration in the control workers. The concentration of urinary TDGA increased in the case of continuous shift, due to the accumulation of residual metabolites of TDGA. It was considered that TDGA3 can be applied as a useful biological index to evaluate the exposure dose of airborne VCM during one day because TDGA3 showed the highest correlation with the exposure dose of airborne VCM in the previous shift day.
Methods: The personal exposure to airborne VCM was assessed and urinary TDGA concentration was sampled in 31 workers employed in a VCM and polyvinyl chloride (PVC) manufacturing factory. Urinary TDGA was sampled three times: before the start of the shift after 3 days off (TDGA1), after the end of the first-day shift (TDGA2) and before starting the following day shift after completing the one-day shift (TDGA3). Urinary TDGA in 30 workers who had not been exposed to airborne VCM was sampled after the end of the shift. A gas chromatography/pulsed flame photometric detector (GC/PFPD) was utilized to analyze TDGA concentration in urine after the urine was methylated with trimethylsilyldia-zomethane (2.0M in diethyl ether).
Results: The creatinine level was 0.179±0.271 ㎎/g in the control workers and 0.218±0.443 ㎎/g in the workers before the start of the shift after 3 days off (TDGA1), showing no significant difference (p=0.7035). Urine samples were compared according to sampling time in order to investigate the change of urinary TDGA concentration in the case of continuous exposure to airborne VCM. In VCM-exposed workers, urinary creatinine concentration was 0.434±0.623 mg/g in TDGA2 and 0.767±1.056 ㎎/g in TDGA3, which indicated a gradual but significant increase (p=0.024). In terms of the statistical correlation between airborne VCM and urinary TDGA to evaluate exposure dose per day, of the three urinary TDGA concentrations, TDGA3 showed the highest degree of regression (R2=0.4215) with 8h-TWA airborne VCM concentration.
Conclusion: Based on this result, the excretion half-life of urinary TDGA was assumed to be less than 3 days, because the concentration of urinary TDGA at 3 days after exposure to airborne VCM was decreased to the level of urinary TDGA concentration in the control workers. The concentration of urinary TDGA increased in the case of continuous shift, due to the accumulation of residual metabolites of TDGA. It was considered that TDGA3 can be applied as a useful biological index to evaluate the exposure dose of airborne VCM during one day because TDGA3 showed the highest correlation with the exposure dose of airborne VCM in the previous shift day.
목차
Abstract
서론
대상 및 방법
연구 결과
고찰
결론
참고문헌
참고문헌 (28)
참고문헌 신청
[학술지(정기간행물)] - / 2005 / Threshold limit values and biological exposure indices
[학술지(정기간행물)] - / jammedassoc1974;229 / Angiosarcoma of the liver following vinyl chloride exposure : 53 ~ 4
[학술지(정기간행물)] - / 2005 / Vinyl chloride-A classical industrial toxicant of new interest 35 : 307 ~ 23
[학술지(정기간행물)] - / 1983 / Sensitive flame-photo-metric-detector analysis of thiodiglycolic acid in urine as a biological monitor of vinyl chloride : 281 ~ 84
[학술지(정기간행물)] - / 2001 / Urinary thiodiglycolic acid levels for vinyl chloride monomer-exposed polyvinyl chloride workers. 43 (11) : 934 ~ 8
[학술지(정기간행물)] - / jammedassoc1974;229 / Angiosarcoma of the liver following vinyl chloride exposure : 53 ~ 4
[학술지(정기간행물)] - / 2005 / Vinyl chloride-A classical industrial toxicant of new interest 35 : 307 ~ 23
[학술지(정기간행물)] - / 1983 / Sensitive flame-photo-metric-detector analysis of thiodiglycolic acid in urine as a biological monitor of vinyl chloride : 281 ~ 84
[학술지(정기간행물)] - / 2001 / Urinary thiodiglycolic acid levels for vinyl chloride monomer-exposed polyvinyl chloride workers. 43 (11) : 934 ~ 8
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UCI(KEPA) : I410-ECN-0101-2009-517-019538126