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    The murine Arrest-defective protein 1225(mARD1225) has been reported to acetylates Lys532 in hypoxia-inducible factor-1α (HIF-1α) and thereby degrades HIF-1α via ubiquitination. Although humanARD1235 (hARD1235) has not effect on HIF-1α degradation but binds and acetylates beta-catenin in vitro. So far, the function of mARD1225 and hARD1235 in vivo still remains unclear. In this study, transgenic mice were generated via microinjection of a DNA construct containing the hARD1235 fused with His9-HRV2-Myc9 gene driven by a chicken beta-actin promoter. Five founders were identified by PCR amplification and Southern bolt analysis. Among them, two founders expressed hARD1235 protein in major organs. hARD1235 transgenic mice ar ... 전체 초록 보기

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      UCI(KEPA) : I410-ECN-0101-2009-510-019516707