지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.6
- 수록면
- 113 - 118 (6page)
이용수
초록· 키워드
오류제보하기
Actin cytoskeletal architecture is believed to be a crucially important modulator of chondrocyte phenotype. 2DG (2-Dexoy-D-glucose) induces reorganization of actin cytoskeletal architecture in chondrocytes. In this study, we have investigated the effects of 2DG on dedifferentiation and inflammation via reorganization of cytoskeletal architecture in rabbit articular chondrocytes, with a focus on p38 kinase pathway. Treatment of 2DG alone reduced type Ⅱ collagen and COX-2 expression in chondrocytes. But, 2DG reduced type Ⅱ collagen was recovered by CD, disruptor of actin cytoskeletal architecture, whereas did not affect on COX-2 expression and production of PGE2 compared with 2DG alone treated cells. Treatment of 2DG with JAS, inducer of cytoskeletal architecture polymerization, accelerated reduction of type Ⅱ collagen expression and synthesis of proteoglycan but did not affect on COX-2 expression and production of PGE<SUB>2.</SUB> Also, 2DG stimulated activation of p38 kinase. This result showed that 2DG regulates type Ⅱ collagen but not cyclooxygenase-2 expression through reorganization of cytoskeletal architecture via p38 kinase pathway in rabbit articular chondrocytes.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
Acknowledgements
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Cytochalasin D Regulates Retinoic Acid Induced COX-2 Expression but not Dedifferentiation via p38kinase Pathway in Rabbit Articular Chondrocytes
대한의생명과학회지
2009 .12
-
Cytochalasin D-induced Matrix Metalloproteinase-2 Regulates Articular Chondrocytes Dedifferentiation
대한의생명과학회지
2008 .09
-
Src Kinase Regulates Nitric Oxide-induced Dedifferentiation and Cyc1ooxygenase-2 Expression in Articular Chondrocytes via p38 Kinase-dependent Pathway
Immune Network
2006 .12
-
p38 Kinase Regulates Nitric Oxide-induced Dedifferentiation and Cyclooxygenase-2 Expression of Articular Chondrocytes
Immune Network
2006 .09
-
Paclitaxel Stimulates Cyclooxygenase-2 Expression via MAP Kinase Pathway in Rabbit Articular Chondrocytes
대한의생명과학회지
2009 .06
-
연골세포의 탈분화 및 세포고사 억제를 위한 기전연구
대한한의학회지
2006 .03
-
Paclitaxel Suppress Dedifferentiation via Mitogen-activated Protein Kinase Pathway in Rabbit Articular Chondrocyte
대한의생명과학회지
2009 .03
-
Modulation of Apoptosis and Differentiation by the Treatment of Sulfasalazine in Rabbit Articular Chondrocytes
Toxicological Research
2016 .04
-
Lysophosphatidic Acid Inhibits Nitric Oxide-induced Apoptosis via p70S6kinase Pathway in Rabbit Articular Chondrocytes
대한의생명과학회지
2009 .12
-
Ectopic Expression of Caveolin-1 Induces COX-2 Expression in Rabbit Articular Chondrocytes via MAP Kinase Pathway
Immune Network
2006 .09
-
COMP-Ang1 accelerates type 2 collagen for maintain normal phenotype in hydrogen peroxide induced rat articular chondrocytes
한국실험동물학회 학술발표대회 논문집
2011 .02
-
The effects of therapeutic ultrasound stimulation on the inflammation cytokine in rat articular chondrocytes
Physical therapy rehabilitation science
2013 .01
-
Resveratrol Inhibits Nitric Oxide-Induced Apoptosis via the NF-Kappa B Pathway in Rabbit Articular Chondrocytes
Biomolecules & Therapeutics(구 응용약물학회지)
2013 .01
-
Inhibition of the Expression of Matrix Metalloproteinases in Articular Chondrocytes by Resveratrol through Affecting Nuclear Factor-Kappa B Signaling Pathway
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Apigenin Regulates Interleukin-1β-Induced Production of Matrix Metalloproteinase Both in the Knee Joint of Rat and in Primary Cultured Articular Chondrocytes
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
Anti-osteoarthritis effects of Pomegranate, Eucommiae cortex and Achyranthis radix extracts on the primary cultured rat articular chondrocytes
대한예방한의학회지
2017 .01
-
Effect of low intensity pulsed ultrasound in activating the mitogen-activated protein kinase signaling pathway and inhibition inflammation cytokine synthesis in chondrocytes
Physical therapy rehabilitation science
2014 .01
-
Luteolin Inhibits the Activity, Secretion and Gene Expression of MMP-3 in Cultured Articular Chondrocytes and Production of MMP-3 in the Rat Knee
Biomolecules & Therapeutics(구 응용약물학회지)
2014 .01
-
Oxysterol 25-hydroxycholesterol as a metabolic pathophysiological factors of osteoarthritis induces apoptosis in primary rat chondrocytes
The Korean Journal of Physiology & Pharmacology
2020 .01
-
흰쥐 퇴행성 관절염모델을 이용한 봉독약침의 치료효과
동의생리병리학회지
2005 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-510-018446133