인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
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지원사업
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커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Objectives：The aim of this study was to investigate the effect of modafinil on daytime sleepiness and cognitive dysfuntion induced by sleep deprivation.
Methods：In this study, 13 healthy young male subjects were examined under following conditions , after normal usual sleep, one night sleep deprivation, one night sleep deprivation followed by 200mg of modafinil ingestion. Subjects visited our laboratory by 08：00 at the first day, and they had baseline multiple sleep latency test(MSLT), and Vienna Test(at 9：00, 11：00, 14：00, and 16：00). Each time. the subjects completed VAS for sleepiness, fatigue, and mood before they underwent an Vienna Test to evaluate their attention, performance, and reaction. They had one night sleep deprivation followed by 200mg of modafinil ingestion and repeated the same process as those of the first day.
Results：After one night total sleep deprivation followed by 200mg of modafinil ingestion, subjective daytime sleepiness, fatigue, and unpleasant mood caused by sleep deprivation were improved, but not to the level of baseline. Increased objective sleepiness measured as sleep latency and total sleep time by MSLT was improved almost to the level of baseline. Impaired continuous attention by sleep deprivation were improved to near those level of baseline. But 200mg of modafinil was not effective for work performance and reaction time.
Conclusion：Not only for those with sleep disorder but also for normal person undergoing sleep deprivation, modafinil is effective for improving sleepiness and fatigue. But additional studies are needed to establish effect of modafinil to attention and performance.
Methods：In this study, 13 healthy young male subjects were examined under following conditions , after normal usual sleep, one night sleep deprivation, one night sleep deprivation followed by 200mg of modafinil ingestion. Subjects visited our laboratory by 08：00 at the first day, and they had baseline multiple sleep latency test(MSLT), and Vienna Test(at 9：00, 11：00, 14：00, and 16：00). Each time. the subjects completed VAS for sleepiness, fatigue, and mood before they underwent an Vienna Test to evaluate their attention, performance, and reaction. They had one night sleep deprivation followed by 200mg of modafinil ingestion and repeated the same process as those of the first day.
Results：After one night total sleep deprivation followed by 200mg of modafinil ingestion, subjective daytime sleepiness, fatigue, and unpleasant mood caused by sleep deprivation were improved, but not to the level of baseline. Increased objective sleepiness measured as sleep latency and total sleep time by MSLT was improved almost to the level of baseline. Impaired continuous attention by sleep deprivation were improved to near those level of baseline. But 200mg of modafinil was not effective for work performance and reaction time.
Conclusion：Not only for those with sleep disorder but also for normal person undergoing sleep deprivation, modafinil is effective for improving sleepiness and fatigue. But additional studies are needed to establish effect of modafinil to attention and performance.
본문·목차
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오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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UCI(KEPA) : I410-ECN-0101-2009-513-018620390
