인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2009.8
- 수록면
- 35 - 38 (4page)
이용수
초록· 키워드
The severe shortage of human organ donors is one of the biggest problems with organ transplantation. The solution to this problem would be the development of artificial organs or mechanical devices, stem cell derived organs, and xenogeneic organs. Artificial organs may provide short term life or functional support, but they cannot be considered as life-long curative therapeutic modality in the near future. Although considerable efforts have been invested in the production of lab-grown organs using stem cells, clinical application of these organs will demand many years of research and investment. Therefore, xenotransplantation would be the most imminent solution to the organ shortage, although the role would be expected as bridge life saver. Recent advances in our understanding of the mechanisms of xenograft rejection, zoonotic infections including PERV (porcine endogenous retrovirus), and production of 1,3-galactosyltransferase-deficient pigs along with genetically modified pigs put xenotransplantation closer to the clinical reality. At this stage, pancreatic islet xenotransplantation would be the first target for clinical application, the efficacy of which has been proven in non-human primate study and is waiting for the development of relatively non-toxic or clinically applicable immunosuppressive or tolerance-inducing regimens. Xenotransplantation Research Center in Seoul National University Hospital launched in 2004, has been working on to make the porcine to human xenotransplantation clinical reality. Non-human primate preclinical studieson pancreatic islet, acellular cornea and heart valve conduit are undergoing. The institutional clinical study will be tried when the non-human primate study proves the safety and better benefit vs. risk gain in the very near future.
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목차
등록된 정보가 없습니다.
참고문헌
참고문헌 신청최근 본 자료
UCI(KEPA) : I410-ECN-0101-2010-510-002004717
