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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.12
- 수록면
- 75 - 82 (8page)
이용수
초록· 키워드
오류제보하기
Anti-mutagenic and anti-septic effects of β-1,3/1,6-glucan from Aureobasidium pullulans SM-2001 were evaluated on the on the cyclophosphamide (CPA)-cecal ligation puncture (CLP) and CPA-treated mice. To induce immunosuppression and mutagenicity, 150 and 110 ㎎/㎏ of CPA were single intraperitoneally injected at 3 or 1 day before CLP or initial β-glucan administration. In CLP animals, the cecum was mobilized and ligated below the ileocecal valve, punctured through both surfaces twice with a 22-gauge needle. 125 ㎎/㎏ of β-glucan were dissolved in saline and subcutaneously or orally administered in a volume of 10 ml/㎏ (of body weight), 4 times, 12 hrs intervals from 6 hrs after CLP or 1 day after second dose of CPA. After treatment of β-glucan, the mortalities were observed in CPA-CLP model, and the appearance of a micronucleus is used as an index for genotoxic potential in CPA model. As results of CPA-CLP sepsis, all animals (9/9, 100%) in CPA-CLP control were dead within 2 days after CLP. In addition, increase of the number of bone marrow MNPCEs indicated mutagenicity were also observed by treatment of CPA. However, β-glucan treatment effectively inhibited the mortalities in CPA-CLP, and it also reduced the CPA treatment-related mutagenicity, respectively. These results indicated that β-glucan has effective anti-septic and anti-mutagenic effects and can be used as an agents for treating sepsis and mutagenicity related to high-dose chemotherapy or radiotherapy. However, further studies should be conducted to observe more detail action mechanisms of it's anti-septic and anti-mutagenic effects.
목차
Ⅰ. Introduction
Ⅱ. Materials and Methods
Ⅲ. Results
Ⅳ. Discussion
Ⅴ. Conclusion
Ⅵ. Acknowledgment
Ⅶ. References
참고문헌 (44)
참고문헌 신청
1. [학술지(정기간행물)] - Hoyert, D.L. / 1999 / Deaths: final data for 1997 / Natl. Vital. Stat. Rep. 47 : 1 ~ 104
2. [학술지(정기간행물)] - Yan, J.J. / 2004 / Therapeutic effects of lysophosphatidylcholine in experimental sepsis / Nat. Med. 10 : 161 ~ 167
3. [학술지(정기간행물)] - Parkman, R. / 1997 / Immunological reconstitution following bone marrow transplantation / Immunol. Rev. 157 : 73 ~ 78
4. [학술지(정기간행물)] - Guillaume, T. / 1998 / Immune reconstitution and immunotherapy after autologous hematopoietic stem cell transplantation / Blood 92 : 1471 ~ 1490
5. [학술지(정기간행물)] - Tzianabos, A.O. / 2000 / Polysaccharide immunomodulators as therapeutic agents: structural aspects and biologic function / Clin. Microbiol. Rev. 13 : 523 ~ 533
2. [학술지(정기간행물)] - Yan, J.J. / 2004 / Therapeutic effects of lysophosphatidylcholine in experimental sepsis / Nat. Med. 10 : 161 ~ 167
3. [학술지(정기간행물)] - Parkman, R. / 1997 / Immunological reconstitution following bone marrow transplantation / Immunol. Rev. 157 : 73 ~ 78
4. [학술지(정기간행물)] - Guillaume, T. / 1998 / Immune reconstitution and immunotherapy after autologous hematopoietic stem cell transplantation / Blood 92 : 1471 ~ 1490
5. [학술지(정기간행물)] - Tzianabos, A.O. / 2000 / Polysaccharide immunomodulators as therapeutic agents: structural aspects and biologic function / Clin. Microbiol. Rev. 13 : 523 ~ 533
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UCI(KEPA) : I410-ECN-0101-2010-519-002517392