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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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DNA vaccine approaches have been applied to generate the protective immunity against various pathogens. However, the strength of immune responses induced by DNA vaccine is weak compared with conventional vaccines. The primeboost vaccination using DNA vaccine and other viral vector has been suggested as one way to circumvent this limitation. In the present study, we used in vivo CTL activity assay to determine CD8? T cell-mediated immunity induced by prime-boost vaccination with a DNA vaccine (gB₄?????? DNA) and recombinant vaccinia virus (VVgB₄??????) expressing gB₄?????? epitope peptide (SSIEFARL) of herpes simplex virus type 1 (HSV-1) glycoprotein B (gB). The most potent in vivo CTL activity was induced in mice received VVgB₄?????? when both gB₄?????? and VVgB₄?????? were used at priming step and boosted with the alternative vaccine vector expressing whole antigen protein (gBw). Priming with vaccine vector expressing gBw followed by the use of VVgB₄?????? at boosting step also induced strong in vivo CTL activity. We also examined in vivo CTL activity after immunization of mice with epitope-expressing vaccine vector at both priming and boosting step. Curiously, in vivo CTL activity mediated by CD8? T cells was strongly elicited at memory stage when animals were primed with VVgB₄?????? and subsequently boosted with gB₄?????? DNA. Because the use of VVgB₄?????? at priming followed by boosting with gB₄?????? DNA induced most optimal immunity, these results suggest that the order of vaccine type should be carefully considered when used vaccine type expressing only epitope for prime-boost vaccination.
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참고문헌 (28)
참고문헌 신청
An LL , 1997 , A multivalent minigene vaccine, containing B-cell, cytotoxic T-lymphocyte, and Th epitopes from several microbes, induces appropriate responses in vivo and confers protection against more than one pathogen 71 : 2292 ~ 302
Bourgeois C , 2002 , A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory 297 : 2060 ~ 2063
Eo SK , 2001 , Prime-boost immunization with DNA vaccine: mucosal route of administration changes the rules 166 : 5473 ~ 5479
Fernando GJ , 2002 , The number of long-lasting functional memory CD8+ T cells generated depends on the nature of the initial nonspecific stimulation 32 : 1541 ~ 1549
Fuller DH , 1997 , Enhancement of immunodeficiency virus-specific immune responses in DNA-immunized rhesus macaques 15 : 924 ~ 926
Bourgeois C , 2002 , A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory 297 : 2060 ~ 2063
Eo SK , 2001 , Prime-boost immunization with DNA vaccine: mucosal route of administration changes the rules 166 : 5473 ~ 5479
Fernando GJ , 2002 , The number of long-lasting functional memory CD8+ T cells generated depends on the nature of the initial nonspecific stimulation 32 : 1541 ~ 1549
Fuller DH , 1997 , Enhancement of immunodeficiency virus-specific immune responses in DNA-immunized rhesus macaques 15 : 924 ~ 926
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UCI(KEPA) : I410-ECN-0101-2010-475-002457003