지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives：Compared with the general population, low incidence of cancers in patients with schizophrenia has been observed. It has been proposed that genetic predisposition toward schizophrenia is associated with reduced vulnerability to cancer. Adenomatous polyposis coli(APC) genes, a tumor suppressor gene, is involved in colorectal tumorigenesis. In order to analyze the genetic difference between Korean schizophrenia and colon cancer patients, polymorphisms of APC gene were studied.
Methods：Two hundred and forty eight schizophrenia patients, 248 colon cancer patients, and 248 control subjects were used to identify the SNPs. Genetic analysis was carried out in the rs2229992 and rs456899 SNP regions using the SNP-IT™ assay. The allele, genotype and haplotype frequencies were compared between the three groups.
Results：The genotype, allele, and haplotype of the APC polymorphisms in schizophrenia patients were not significant different from those of controls. When compared colon cancer patients, the schizophrenia patients showed significantly more frequent in rs2229992 CT/TT genotype(odds ratio 2.179, 95% confidence interval(CI)=1.20-3.959) and the male schizophrenia patients revealed significant differences in T-G haplotype(odds ratio 2.5915, 95% CI=1.4677-4.5759), after adjusting for age and sex.
Conclusion：These results suggest that the APC polymorphisms found in schizophrenia patients, especially in males, may be associated with reduced vulnerability to colon cancer.
Methods：Two hundred and forty eight schizophrenia patients, 248 colon cancer patients, and 248 control subjects were used to identify the SNPs. Genetic analysis was carried out in the rs2229992 and rs456899 SNP regions using the SNP-IT™ assay. The allele, genotype and haplotype frequencies were compared between the three groups.
Results：The genotype, allele, and haplotype of the APC polymorphisms in schizophrenia patients were not significant different from those of controls. When compared colon cancer patients, the schizophrenia patients showed significantly more frequent in rs2229992 CT/TT genotype(odds ratio 2.179, 95% confidence interval(CI)=1.20-3.959) and the male schizophrenia patients revealed significant differences in T-G haplotype(odds ratio 2.5915, 95% CI=1.4677-4.5759), after adjusting for age and sex.
Conclusion：These results suggest that the APC polymorphisms found in schizophrenia patients, especially in males, may be associated with reduced vulnerability to colon cancer.
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UCI(KEPA) : I410-ECN-0101-2010-513-003100539