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논문 기본 정보

자료유형
학술저널
저자정보
Hyun Ju Hong (제주대학교) Ju Youn Jin (제주대학교) Heekyoung Yang (제주대학교) Won Young Kang (제주대학교) Dong Geon Kim (제주대학교) Sunyi Lee (농촌진흥청) Younghun Choi (농촌진흥청) Jae Hoon Kim (제주대학교) Chang Hoon Han (제주대학교) Young Jae Lee (제주대학교)
저널정보
한국실험동물학회 Laboratory Animal Research Laboratory Animal Research Vol.26 No.4
발행연도
2010.12
수록면
361 - 367 (7page)

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Obesity is a major public health problem and significant risk factor for many serious diseases including coronary artery disease, cancer, and diabetes. This study was performed to investigate the hypolipidemic effects and anti-hypertensive effect of Dangyuja (Citrus grandis Osbeck) peel, which is bred on Jeju island, in rats fed a high-fat diet. This study was conducted on 4 equal rat groups which were fed as follows; normal diet group (ND), high fat diet group (HFD), high fat diet supplemented with powdered peel of Dangyuja (1%, wt/wt) group (HFD+Dangyuja), and high fat diet treated with sibutramine simultaneously at a dose of 10 ㎎/㎏ group (HFD+Sibutramine). After feeding the high fat diet, body weight gain and relative weight of adipose tissues and liver significantly increased in HFD group, but Dangyuja peel supplementation protected these HFD-induced changes. The levels of serum triglyceride, total cholesterol, low-density lipoprotein (LDL)-cholesterol, and the atherogenic index significantly decreased in the HFD+Dangyuja peel group compared with the HFD group. The systolic blood pressure was significantly increased by feeding the high fat diet, whereas the supplementation of Dangyuja peel effectively prevented the elevation of blood pressure. Therefore, these results suggest that Dangyuja exerts a beneficial effect on obesity by improving lipid metabolism and alleviating obesity-related hypertension.

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