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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.2
- 수록면
- 24 - 30 (7page)
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The anti-cancer effects of Angelica keiskei ethanol extract were evaluated in human breast cancer MDA-MB-231 cells. The concentrations of extract were 1, 2, 3, 4 and 5 ㎎/mL. Dose-dependent reductions in the number of cells with altered cell shape and pyknotic nuclei were observed at 48 h after treatments. MTT assay also exhibited a similar dose-dependent reduction in mitochondrial reductase activity (p＜0.05), in particular, with a rapid reduction in the activity of the 5 ㎎/mL group. Analysis of cell death with propidium iodide (PI) staining revealed only a slight increase in cell death in the 5 ㎎/mL group. Analysis of bromodeoxyuridine (BrdU) incorporations also showed a dose-dependent reduction in cell proliferation (p＜0.05). Finally, increases in total radical oxygen species (ROS) accumulation in cells, as revealed by DCF-DA staining, were observed in the treated groups in a similar dose-dependent fashion (p＜0.05). These results indicate that Angelica keiskei ethanol extract exhibiting anti-cancer effects in MDA-MB-231 cells causes multiple changes in cell shape, enzyme activity, and ROS accumulation, thereby inducing cell death.
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Abstract
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재료 및 방법
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참고문헌 (31)
참고문헌 신청
1. [학술지(정기간행물)] - Akihisa T / 2003 / Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects / Cancer Lett 201 : 133 ~ 137
2. [단행본] - American Institute of Cancer Research / 2007 / Food, nutrition, physical activity, and prevention of cancer: A global perspective / American Institute of Cancer Research
3. [학술지(정기간행물)] - Baba K / 1998 / Studies on Angelica keiskei Ashitaba / Foods Food Ingredients J Jpn 178 : 52 ~ 60
4. [학술지(정기간행물)] - Benhar M / 2002 / ROS, stress-activated kinases and stress signaling in cancer / EMBO Reports 5 : 420 ~ 425
5. [학술지(정기간행물)] - Brandi G / 2005 / Machanisms of action and antiproliferative properties of Brassica oleracea juice in human breast cancer cell lines / J Nutr 135 : 1503 ~ 1509
2. [단행본] - American Institute of Cancer Research / 2007 / Food, nutrition, physical activity, and prevention of cancer: A global perspective / American Institute of Cancer Research
3. [학술지(정기간행물)] - Baba K / 1998 / Studies on Angelica keiskei Ashitaba / Foods Food Ingredients J Jpn 178 : 52 ~ 60
4. [학술지(정기간행물)] - Benhar M / 2002 / ROS, stress-activated kinases and stress signaling in cancer / EMBO Reports 5 : 420 ~ 425
5. [학술지(정기간행물)] - Brandi G / 2005 / Machanisms of action and antiproliferative properties of Brassica oleracea juice in human breast cancer cell lines / J Nutr 135 : 1503 ~ 1509
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UCI(KEPA) : I410-ECN-0101-2012-594-004189404